{"id":438,"date":"2022-08-10T14:19:11","date_gmt":"2022-08-10T18:19:11","guid":{"rendered":"https:\/\/campsiitestudy.com\/home\/"},"modified":"2023-06-09T10:00:24","modified_gmt":"2023-06-09T14:00:24","slug":"home","status":"publish","type":"page","link":"https:\/\/campsiitestudy.com\/es\/","title":{"rendered":"Home"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"438\" class=\"elementor elementor-438 elementor-8\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-40f7629 elementor-section-stretched hero-row elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"40f7629\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a2ee3e4\" data-id=\"a2ee3e4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d6dc30d elementor-widget__width-auto elementor-absolute header-illustration cloud-1 elementor-widget elementor-widget-image\" data-id=\"d6dc30d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"245\" height=\"94\" src=\"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2022\/08\/cloud-1-1.svg\" class=\"attachment-full size-full wp-image-320\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a5d0669 elementor-widget__width-auto elementor-absolute header-illustration cloud-2 elementor-widget elementor-widget-image\" data-id=\"a5d0669\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"212\" height=\"89\" src=\"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2022\/08\/cloud-2.svg\" class=\"attachment-full size-full wp-image-293\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8c13e9e elementor-widget__width-auto elementor-absolute header-illustration cloud-3 elementor-widget elementor-widget-image\" data-id=\"8c13e9e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"245\" height=\"94\" src=\"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2022\/08\/cloud-3.svg\" class=\"attachment-full size-full wp-image-296\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-43b39a0 elementor-widget__width-auto elementor-absolute header-illustration sun elementor-widget elementor-widget-image\" data-id=\"43b39a0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_effect&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_direction&quot;:&quot;negative&quot;,&quot;motion_fx_translateY_speed&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1,&quot;sizes&quot;:[]},&quot;motion_fx_translateY_affectedRange&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:0,&quot;end&quot;:100}},&quot;motion_fx_devices&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"224\" height=\"224\" src=\"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2022\/08\/sun.svg\" class=\"attachment-full size-full wp-image-302\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-4c3a7ed hero-inner-row elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4c3a7ed\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-db3c32b\" data-id=\"db3c32b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3cd8d7c elementor-widget elementor-widget-text-editor\" data-id=\"3cd8d7c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h1>Un tratamiento en investigaci\u00f3n \u00fanico para la mucopolisacaridosis tipo II (s\u00edndrome de Hunter)<\/h1>\n<p>REGENXBIO, l\u00edder mundial en terapia g\u00e9nica con VAA, est\u00e1 actualmente inscribiendo participantes en un ensayo cl\u00ednico de RGX-121, una terapia g\u00e9nica \u00fanica en investigaci\u00f3n para el posible tratamiento de la mucopolisacaridosis tipo II, tambi\u00e9n conocida como MPS II o s\u00edndrome de Hunter. El ensayo cl\u00ednico, llamado estudio CAMPSIITE\u2122, evaluar\u00e1 el efecto de RGX-121 en varones con MPS II<sup>1<\/sup> neuronop\u00e1tica entre las edades de 4 meses y 5 a\u00f1os. <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c51415d cta-wrapper elementor-widget elementor-widget-text-editor\" data-id=\"c51415d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a class=\"button\" href=\"#campsiite-study\">M\u00e1s informaci\u00f3n sobre <span class=\"large-cta-text\">CAMPSIITE<\/span><\/a><\/p><p><a class=\"text-link\" href=\"#contact-us\"><span class=\"large-cta-text\">P\u00f3ngase en contacto con nosotros<\/span><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-eee5159\" data-id=\"eee5159\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-39d4ca0 elementor-widget__width-auto elementor-absolute header-illustration tree-2 elementor-widget elementor-widget-image\" data-id=\"39d4ca0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_effect&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_speed&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1,&quot;sizes&quot;:[]},&quot;motion_fx_translateY_affectedRange&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:0,&quot;end&quot;:100}},&quot;motion_fx_devices&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"392\" src=\"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2022\/08\/tree-2.svg\" class=\"attachment-full size-full wp-image-305\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d4c8bb elementor-widget__width-auto elementor-absolute header-illustration tree-1 elementor-widget elementor-widget-image\" data-id=\"4d4c8bb\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_effect&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_speed&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1,&quot;sizes&quot;:[]},&quot;motion_fx_translateY_affectedRange&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:0,&quot;end&quot;:100}},&quot;motion_fx_devices&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"261\" src=\"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2022\/08\/tree-1.svg\" class=\"attachment-full size-full wp-image-299\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6d44d7b elementor-widget__width-auto elementor-absolute header-illustration tree-3 elementor-widget elementor-widget-image\" data-id=\"6d44d7b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_effect&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_speed&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1.5,&quot;sizes&quot;:[]},&quot;motion_fx_devices&quot;:[&quot;desktop&quot;],&quot;motion_fx_translateY_affectedRange&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:0,&quot;end&quot;:100}}}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"261\" src=\"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2022\/08\/tree-3.svg\" class=\"attachment-full size-full wp-image-308\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6e4ee1a elementor-widget__width-auto elementor-absolute header-illustration tree-4 elementor-widget elementor-widget-image\" data-id=\"6e4ee1a\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_effect&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_speed&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1,&quot;sizes&quot;:[]},&quot;motion_fx_devices&quot;:[&quot;desktop&quot;],&quot;motion_fx_translateY_affectedRange&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:0,&quot;end&quot;:100}}}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"523\" src=\"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2022\/08\/tree-4.svg\" class=\"attachment-full size-full wp-image-311\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8fccfaf elementor-widget__width-auto elementor-absolute header-illustration tent elementor-widget elementor-widget-image\" data-id=\"8fccfaf\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_effect&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_speed&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1.5,&quot;sizes&quot;:[]},&quot;motion_fx_devices&quot;:[&quot;desktop&quot;],&quot;motion_fx_translateY_affectedRange&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:0,&quot;end&quot;:100}}}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"235\" src=\"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2022\/08\/tent.svg\" class=\"attachment-full size-full wp-image-290\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-752a9f8 elementor-section-stretched light-green-row elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"752a9f8\" data-element_type=\"section\" data-e-type=\"section\" id=\"about-hunter-syndrome\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-833a9fc\" data-id=\"833a9fc\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c9b777a elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"c9b777a\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>Acerca del s\u00edndrome de Hunter<\/h2>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f550e32 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"f550e32\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>\u00bfQu\u00e9 es la mucopolisacaridosis tipo II (MPS II)?<\/h3>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-0a5e48a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0a5e48a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-871209e narrow-col\" data-id=\"871209e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c03adcc elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"c03adcc\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La MPS II, o s\u00edndrome de Hunter, es una enfermedad gen\u00e9tica poco frecuente que se produce en aproximadamente uno de cada 100.000 a 170.000 varones nacidos.<sup>1<\/sup><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-56c449c elementor-invisible elementor-widget elementor-widget-image\" data-id=\"56c449c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"463\" height=\"326\" src=\"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/06\/stat-es-1.svg\" class=\"attachment-full size-full wp-image-570\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-487f125 callout-column elementor-invisible\" data-id=\"487f125\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:150}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-856d904 elementor-widget elementor-widget-text-editor\" data-id=\"856d904\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n<li>Las personas que viven con MPS II tienen una mutaci\u00f3n en el gen responsable de producir una enzima llamada iduronato-2-sulfatasa (<em>IDS<\/em>). <sup>1<\/sup><\/li>\n<li>Las c\u00e9lulas necesitan esta enzima para descomponer largas cadenas de mol\u00e9culas de az\u00facar conocidas como glicosaminoglicanos(GAG). <sup>1<\/sup><\/li>\n<li>Si los GAG se acumulan en las c\u00e9lulas del cuerpo, pueden causar da\u00f1o progresivo en muchos \u00f3rganos, incluidos el cerebro, los o\u00eddos, los pulmones, el coraz\u00f3n, el est\u00f3mago, los intestinos, los huesos, las articulaciones, la boca y la piel. <sup>2<\/sup><\/li>\n<li>El da\u00f1o resultante de la acumulaci\u00f3n de GAG en las c\u00e9lulas es irreversible, lo que destaca la importancia del diagn\u00f3stico y el tratamiento tempranos. <sup>4<\/sup><\/li>\n<li>Los tratamientos aprobados actualmente para el s\u00edndrome de Hunter no abordan el impacto de la MPS II en el cerebro. <sup>3<\/sup><\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-5755108 card card-row elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"5755108\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-348fe74\" data-id=\"348fe74\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9feb85f elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"9feb85f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>C\u00e9lula sana frente a c\u00e9lula con MPS II<\/h3>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b82149c screen-reader-text elementor-widget elementor-widget-text-editor\" data-id=\"b82149c\" data-element_type=\"widget\" data-e-type=\"widget\" id=\"overview-of-cell\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>C\u00c9LULA SANA<\/h3>\n<ol>\n<li>Glicosaminoglicanos (GAG): Mol\u00e9culas de az\u00facar resultantes de las funciones celulares normales<\/li>\n<li>El ADN normal codifica diversas enzimas que descomponen los GAG<\/li>\n<\/ol>\n<p>Enzimas (estas enzimas se encuentran en el lisosoma, no flotando alrededor del citoplasma, por lo que la enfermedad es de dep\u00f3sito lisosomal)<\/p>\n<ol start=\"3\">\n<li>Las enzimas descomponen los GAG<\/li>\n<\/ol>\n<h3>C\u00c9LULA CON MPS II NEURONOP\u00c1TICA<\/h3>\n<ol start=\"4\">\n<li>El ADN contiene un c\u00f3digo defectuoso para producir una enzima espec\u00edfica que descompone los GAG<\/li>\n<\/ol>\n<p>Citoplasma (en el lisosoma, no en el citoplasma)<\/p>\n<ol start=\"5\">\n<li>Las enzimas solo descomponen parcialmente los GAG, lo que resulta en su acumulaci\u00f3n dentro de la c\u00e9lula<\/li>\n<li> En pacientes con MPS II neuronop\u00e1tica, la acumulaci\u00f3n de GAG provoca da\u00f1os en tejidos y \u00f3rganos de todo el cuerpo, incluida la neurodegeneraci\u00f3n.<\/li>\n<\/ol>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3db6687 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"3db6687\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" aria-describedby=\"overview-of-cell\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/06\/A-Spanish.jpg\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"A Spanish\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NTE1LCJ1cmwiOiJodHRwczpcL1wvY2FtcHNpaXRlc3R1ZHkuY29tXC93cC1jb250ZW50XC91cGxvYWRzXC8yMDIzXC8wNlwvQS1TcGFuaXNoLmpwZyJ9\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"2000\" height=\"959\" src=\"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/06\/A-Spanish.jpg\" class=\"attachment-full size-full wp-image-515\" alt=\"\" srcset=\"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/06\/A-Spanish.jpg 2000w, https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/06\/A-Spanish-300x144.jpg 300w, https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/06\/A-Spanish-1024x491.jpg 1024w, https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/06\/A-Spanish-768x368.jpg 768w, https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/06\/A-Spanish-1536x737.jpg 1536w\" sizes=\"(max-width: 2000px) 100vw, 2000px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-3b755cc elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3b755cc\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>Tipos de MPS II<\/h3>\n<p>Por lo general, existen dos tipos de MPS II, que var\u00edan ampliamente en t\u00e9rminos de gravedad, tasa de progresi\u00f3n y edad de inicio. <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-1c90de7 callout-row elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1c90de7\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-7b9bfa3 card elementor-invisible\" data-id=\"7b9bfa3\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fbdfcf9 elementor-widget elementor-widget-text-editor\" data-id=\"fbdfcf9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4>Atenuada<\/h4>\n<p>En la MPS II atenuada, la enfermedad progresa lentamente, con un impacto m\u00ednimo o nulo en el cerebro o en el desarrollo intelectual.<sup>1<\/sup><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-192b8b2 card\" data-id=\"192b8b2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-78afd28 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"78afd28\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_delay&quot;:150}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4>Neuronop\u00e1tica<\/h4>\n<p>En la MPS II neuronop\u00e1tica, tambi\u00e9n conocida como MPS II grave, existe una tasa m\u00e1s r\u00e1pida de progresi\u00f3n de la enfermedad y un impacto significativo en el cerebro y el desarrollo intelectual.<sup>1<\/sup> La MPS II neuronop\u00e1tica representa hasta el 70%<sup>2<\/sup> de las incidencias de la enfermedad.<sup>6<\/sup><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-759e5ec elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"759e5ec\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-d8a829b elementor-invisible\" data-id=\"d8a829b\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3dc3643 elementor-widget elementor-widget-text-editor\" data-id=\"3dc3643\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>En la MPS II grave, o la forma neuronop\u00e1tica, un ni\u00f1o puede cumplir los hitos del desarrollo temprano, pero la tasa de adquisici\u00f3n de habilidades se ralentiza al principio del desarrollo (normalmente entre 12 y 24 meses despu\u00e9s del nacimiento). Este retraso se hace m\u00e1s evidente con el tiempo, con capacidades de desarrollo neurol\u00f3gico (aprendizaje y comprensi\u00f3n, lenguaje expresivo) y habilidades motoras finas que se mueven fuera del intervalo normal entre los 24 y los 29 meses. La adquisici\u00f3n de habilidades generalmente se estabiliza alrededor de los 5 a 6 a\u00f1os de edad, con el ni\u00f1o funcionando a un nivel de desarrollo similar al de un ni\u00f1o no afectado de 2 a 3 a\u00f1os de edad.<sup>1-5<\/sup>  <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-c457825 elementor-invisible\" data-id=\"c457825\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:150}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c56a66d neuro-activities-ul elementor-widget elementor-widget-text-editor\" data-id=\"c56a66d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Las actividades del neurodesarrollo incluyen:<\/p><ul><li>Aprendizaje<\/li><li>Comprensi\u00f3n<\/li><li>Lenguaje expresivo<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-9452835 elementor-widget-divider--view-line elementor-invisible elementor-widget elementor-widget-divider\" data-id=\"9452835\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;,&quot;_animation_delay&quot;:150}\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ffebf0b symptoms elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"ffebf0b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>S\u00edntomas<\/h3>\n<p>Los ni\u00f1os con MPS II pueden presentar diversos s\u00edntomas, dependiendo de la edad de aparici\u00f3n y la gravedad de la afecci\u00f3n:<sup>1,2,6<\/sup><\/p>\n<ul>\n<li>Otitis recurrentes<\/li>\n<li>Hernia umbilical o inguinal (protuberancia de parte del intestino a trav\u00e9s de la abertura en los m\u00fasculos abdominales o en la regi\u00f3n inguinal)<\/li>\n<li>Hidrocefalia (acumulaci\u00f3n de l\u00edquido en las profundidades del cerebro)<\/li>\n<li>Engrosamiento de las fosas nasales y los labios<\/li>\n<li>Macrocefalia (una cabeza m\u00e1s grande de lo normal)<\/li>\n<li>Macroglosia (lengua mayor de lo normal)<\/li>\n<li>Hepatoesplenomegalia (aumento del tama\u00f1o del bazo y del h\u00edgado)<\/li>\n<li>P\u00e9rdida de audici\u00f3n<\/li>\n<li>Am\u00edgdalas agrandadas<\/li>\n<li>Voz ronca<\/li>\n<li>Trastornos del sue\u00f1o<\/li>\n<li>Baja estatura<\/li>\n<li>Articulaciones r\u00edgidas y movimiento articular limitado<\/li>\n<li>S\u00edndrome del t\u00fanel carpiano<\/li>\n<li>Retraso del crecimiento<\/li>\n<li>Aparici\u00f3n tard\u00eda de los dientes o espacios amplios entre ellos<\/li>\n<li>Crecimientos blancos en la piel<\/li>\n<li>Deterioro del neurodesarrollo, discapacidad intelectual<\/li>\n<li>Problemas conductuales (hiperactividad, problemas de atenci\u00f3n, destructividad, falta de miedo)<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5573f1b elementor-widget-divider--view-line elementor-invisible elementor-widget elementor-widget-divider\" data-id=\"5573f1b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;,&quot;_animation_delay&quot;:150}\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-833d0e3 additional-resources elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"833d0e3\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>Recursos Adicionales<\/h3>\n<p>Para obtener m\u00e1s informaci\u00f3n sobre la MPS II, visite los siguientes enlaces:<\/p>\n<ul>\n<li><a href=\"https:\/\/mpssociety.org\/\" target=\"_blank\" rel=\"noopener\">National MPS Society (U.S.)<\/a> (sitio web disponible en el siguiente idioma: ingl\u00e9s)<\/li>\n<li><a href=\"https:\/\/projectalive.org\/\" target=\"_blank\" rel=\"noopener\">Project Alive<\/a> (sitio web disponible en el siguiente idioma: ingl\u00e9s)<\/li>\n<li><a href=\"https:\/\/rarediseases.org\/rare-diseases\/mucopolysaccharidosis-type-ii-2\/\" target=\"_blank\" rel=\"noopener\">National Organization for Rare Disorders (NORD)<\/a> (sitio web disponible en el siguiente idioma: ingl\u00e9s)<\/li>\n<li><a href=\"https:\/\/casahunter.org.br\/home-en\/\" target=\"_blank\" rel=\"noopener\">Casa Hunter (Brasil)<\/a> (sitio web disponible en los siguientes idiomas: ingl\u00e9s, portugu\u00e9s)<\/li>\n<li><a href=\"https:\/\/www.mpssociety.ca\/\" target=\"_blank\" rel=\"noopener\">Canadian MPS Society for Mucopolysaccharide &amp; Related Diseases<\/a> (sitio web disponible en el siguiente idioma: ingl\u00e9s)<\/li>\n<li><a href=\"https:\/\/www.orpha.net\/consor\/cgi-bin\/Disease_Search.php?lng=EN&amp;data_id=131&amp;Disease_Disease_Search_diseaseGroup=mpsii&amp;Disease_Disease_Search_diseaseType=Pat&amp;Disease(s)\/group%20of%20diseases=Mucopolysaccharidosis-type-2&amp;title=Mucopolysaccharidosis%20type%202&amp;search=Disease_Search_Simple\" target=\"_blank\" rel=\"noopener\">Orphanet<\/a> (sitio web disponible en los siguientes idiomas: checo, holand\u00e9s, ingl\u00e9s, franc\u00e9s, alem\u00e1n, italiano, polaco, portugu\u00e9s, espa\u00f1ol)<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7001f8b elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"7001f8b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>Recursos Adicionales<\/h3>\n<p>Para obtener m\u00e1s informaci\u00f3n sobre la MPS II, visite los siguientes enlaces:<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-1c3c54a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1c3c54a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-e8aa059 elementor-invisible\" data-id=\"e8aa059\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2ebc498 elementor-widget elementor-widget-text-editor\" data-id=\"2ebc498\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/mpssociety.org\/\" target=\"_blank\" rel=\"noopener\">National MPS Society (U.S.)<\/a> (sitio web disponible en el siguiente idioma: ingl\u00e9s)<\/p>\n<p><a href=\"https:\/\/projectalive.org\/\" target=\"_blank\" rel=\"noopener\">Project Alive<\/a> (sitio web disponible en el siguiente idioma: ingl\u00e9s)<\/p>\n<p><a href=\"https:\/\/rarediseases.org\/rare-diseases\/mucopolysaccharidosis-type-ii-2\/\" target=\"_blank\" rel=\"noopener\">National Organization for Rare Disorders (NORD)<\/a> (sitio web disponible en el siguiente idioma: ingl\u00e9s)<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-017f38e elementor-invisible\" data-id=\"017f38e\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e4b74de elementor-widget elementor-widget-text-editor\" data-id=\"e4b74de\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/casahunter.org.br\/home-en\/\" target=\"_blank\" rel=\"noopener\">Casa Hunter (Brasil)<\/a> (sitio web disponible en los siguientes idiomas: ingl\u00e9s, portugu\u00e9s)<\/p>\n<p><a href=\"https:\/\/www.mpssociety.ca\/\" target=\"_blank\" rel=\"noopener\">Canadian MPS Society for Mucopolysaccharide &amp; Related Diseases<\/a> (sitio web disponible en el siguiente idioma: ingl\u00e9s)<\/p>\n<p><a href=\"https:\/\/www.orpha.net\/consor\/cgi-bin\/Disease_Search.php?lng=EN&amp;data_id=131&amp;Disease_Disease_Search_diseaseGroup=mpsii&amp;Disease_Disease_Search_diseaseType=Pat&amp;Disease(s)\/group%20of%20diseases=Mucopolysaccharidosis-type-2&amp;title=Mucopolysaccharidosis%20type%202&amp;search=Disease_Search_Simple\" target=\"_blank\" rel=\"noopener\">Orphanet<\/a> (sitio web disponible en los siguientes idiomas: checo, holand\u00e9s, ingl\u00e9s, franc\u00e9s, alem\u00e1n, italiano, polaco, portugu\u00e9s, espa\u00f1ol)<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-e679602 references elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e679602\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>Referencias<\/h3>\n<ol>\n<li>Rare Disease Database: Mucopolysaccharidosis type II. NORD \u2013 National Organization for Rare Disorders, Inc.; 2021 <a href=\"https:\/\/rarediseases.org\/rare-diseases\/mucopolysaccharidosis-type-ii-2\/\">https:\/\/rarediseases.org\/rare-diseases\/mucopolysaccharidosis-type-ii-2\/.<\/a><\/li>\n<li>Escolar ML, Jones SA, Shapiro EG, Horovitz DDG, Lampe C, Amartino H. Practical management of behavioral problems in mucopolysaccharidoses disorders. <em>Mol Genet Metab. <\/em>2017;122:35-40.<\/li>\n<li>D\u2019Avanzo F, Rigon L, Zanetti A, Tomanin R. Mucopolysaccharidosis type II: one hundred years of research, diagnosis, and treatment. <em>Int J Mol Sci. <\/em>2020;21:1258.<\/li>\n<li>Muenzer J, Bodamer O, Burton B, et al. The role of enzyme replacement therapy in severe Hunter syndrome \u2013 an expert panel consensus. <em>Eur J Pediatr. <\/em>2012;171:181-188.<\/li>\n<li>Escolar M, Phillips D, Cho Y, Mulatya C, Nevoret M-L, Poe M. Natural history of neurodevelopment in neuronopathic mucopolysaccharidosis type II (MPS II): Mullen Scales of Early Learning (MSEL) visual reception, expressive and receptive language and fine motor scale developmental trajectories. Presented at 2022 annual symposium of the Society for the Study of Inborn Errors of Metabolism (SSIEM), Freiburg, Germany, August 2022. Abstract SSIEM22-2814.<\/li>\n<li>Scarpa M. Mucopolysaccharidosis type II. GeneReviews\u00ae [Internet]; 2018. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1274\/\">https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1274\/<\/a>. <\/li>\n<\/ol>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a8b0ee9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a8b0ee9\" data-element_type=\"section\" data-e-type=\"section\" id=\"about-rgx-121-gene-therapy\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e502aab\" data-id=\"e502aab\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4bbae4d elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"4bbae4d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>Acerca de la terapia g\u00e9nica RGX-121<\/h2>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-505869f elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"505869f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>\u00bfQu\u00e9 son los genes y la terapia g\u00e9nica?<sup>1-3<\/sup><\/h3><p>Cada c\u00e9lula del cuerpo humano contiene cromosomas compuestos de genes. Estos genes consisten en ADN, que proporciona instrucciones que indican al organismo c\u00f3mo producir prote\u00ednas, que son un componente esencial de nuestro organismo. El cuerpo humano contiene miles de genes.<\/p><p>La terapia g\u00e9nica es un tratamiento que implica la introducci\u00f3n, eliminaci\u00f3n o cambio en el material gen\u00e9tico en las c\u00e9lulas de una persona. Existen varios enfoques para la terapia g\u00e9nica:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-43ac9e3 callout-row elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"43ac9e3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-0088591 card orange-outline elementor-invisible\" data-id=\"0088591\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bfc9cc1 elementor-widget elementor-widget-text-editor\" data-id=\"bfc9cc1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4>Adici\u00f3n de genes<\/h4>\n<p>La entrega de un gen a una persona, lo que permite que el cuerpo de esa persona produzca una prote\u00edna funcional (tambi\u00e9n denominada a veces sustituci\u00f3n g\u00e9nica). RGX-121 utiliza este enfoque. <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-8c25e4a card elementor-invisible\" data-id=\"8c25e4a\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:150}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6f91ba6 elementor-widget elementor-widget-text-editor\" data-id=\"6f91ba6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4>Edici\u00f3n de genes<\/h4>\n<p>Inserci\u00f3n, sustituci\u00f3n o eliminaci\u00f3n de ADN defectuoso en un gen.<sup>2-3<\/sup><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-0b5df88 card elementor-invisible\" data-id=\"0b5df88\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:300}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dfcf760 elementor-widget elementor-widget-text-editor\" data-id=\"dfcf760\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4>Modificaci\u00f3n del ARN<\/h4>\n<p>La modificaci\u00f3n del ARN (una mol\u00e9cula similar al ADN que ayuda a la c\u00e9lula a crear prote\u00ednas a partir de los genes) para bloquear la producci\u00f3n de prote\u00ednas disfuncionales a partir de un gen mutado.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-c09acb4 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"c09acb4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>\u00bfQu\u00e9 es la tecnolog\u00eda NAV<sup>\u00ae<\/sup>?<\/h3>\n<p>Las terapias g\u00e9nicas de REGENXBIO se est\u00e1n investigando en ensayos cl\u00ednicos y est\u00e1n dise\u00f1adas para administrar genes de trabajo a c\u00e9lulas que utilizan vectores del virus adenoasociado (VAA) como \u201cveh\u00edculos\u201d de administraci\u00f3n. Los vectores VAA son virus modificados que no pueden aumentar su n\u00famero ni reproducirse por s\u00ed mismos y que se sabe que no causan enfermedades en los seres humanos. <\/p>\n<p>Nuestras terapias g\u00e9nicas en investigaci\u00f3n utilizan vectores v\u00edricos de nuestra plataforma patentada de administraci\u00f3n g\u00e9nica, lo que llamamos plataforma tecnol\u00f3gica NAV<sup>\u00ae<\/sup>. Miles de pacientes han recibido terapias g\u00e9nicas VAA derivadas de nuestra plataforma tecnol\u00f3gica NAV. <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-178efa4 elementor-invisible elementor-widget elementor-widget-video\" data-id=\"178efa4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;vimeo&quot;,&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<iframe class=\"elementor-video-iframe\" allowfullscreen allow=\"clipboard-write\" title=\"Reproductor de v\u00eddeo vimeo\" src=\"https:\/\/player.vimeo.com\/video\/152453737?color&amp;autopause=0&amp;loop=0&amp;muted=0&amp;title=1&amp;portrait=1&amp;byline=1#t=\"><\/iframe>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-114e336 elementor-widget-divider--view-line elementor-invisible elementor-widget elementor-widget-divider\" data-id=\"114e336\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;,&quot;_animation_delay&quot;:150}\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-4fa8fc4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4fa8fc4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-b67c630 narrow-col elementor-invisible\" data-id=\"b67c630\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b488f29 elementor-widget elementor-widget-text-editor\" data-id=\"b488f29\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>\u00bfQu\u00e9 es RGX-121?<\/h3>\n<p>RGX-121 es una terapia g\u00e9nica en investigaci\u00f3n \u00fanica para el posible tratamiento de la MPS II. Est\u00e1 dise\u00f1ado para utilizar el vector NAV<sup>\u00ae<\/sup> AAV9 para administrar el gen de la iduronato-2-sulfatasa (<em>IDS<\/em>) humano directamente al l\u00edquido que rodea al cerebro, que se conoce como l\u00edquido cefalorraqu\u00eddeo (LCR). <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3090435 callout-column elementor-invisible\" data-id=\"3090435\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e048b5f elementor-widget elementor-widget-text-editor\" data-id=\"e048b5f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n<li>Una vez que el vector NAV<sup>\u00ae<\/sup> AAV9 suministra el gen IDS a las c\u00e9lulas del cerebro, <strong>las c\u00e9lulas pueden comenzar a producir la enzima I2S necesaria<\/strong> y podr\u00edan proporcionar una fuente permanente de I2S en el sistema nervioso central (SNC) que consiste en el cerebro y la m\u00e9dula espinal.<\/li>\n<li>La producci\u00f3n continua de la enzima <strong>puede evitar el deterioro del neurodesarrollo<\/strong> en ni\u00f1os que reciben la terapia g\u00e9nica en una etapa temprana de la vida y puede impedir que el da\u00f1o empeore en ni\u00f1os que reciben la terapia g\u00e9nica a una edad m\u00e1s avanzada.<\/li>\n<li>A diferencia de los tratamientos disponibles actualmente para la MPS II, RGX-121 puede atravesar la barrera hematoencef\u00e1lica (BHE), una red protectora de vasos sangu\u00edneos y c\u00e9lulas que separa el SNC del resto del cuerpo. Al cruzar la BHE del SNC para alcanzar el resto del cuerpo, RGX-121 <strong>puede abordar los efectos sist\u00e9micos<\/strong> (aquellos que afectan al cuerpo en su totalidad) de la MPS II.<sup>4<\/sup> <\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-31a73ac card card-row elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"31a73ac\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-1092c6a\" data-id=\"1092c6a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2340660 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"2340660\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>C\u00f3mo est\u00e1 previsto que funcione RGX-121<\/h3>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-99df42d elementor-invisible elementor-widget elementor-widget-image\" data-id=\"99df42d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" aria-describedby=\"transporter\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/06\/B-Spanish.jpg\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"B Spanish\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NTE5LCJ1cmwiOiJodHRwczpcL1wvY2FtcHNpaXRlc3R1ZHkuY29tXC93cC1jb250ZW50XC91cGxvYWRzXC8yMDIzXC8wNlwvQi1TcGFuaXNoLmpwZyJ9\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"2000\" height=\"1096\" src=\"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/06\/B-Spanish.jpg\" class=\"attachment-full size-full wp-image-519\" alt=\"\" srcset=\"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/06\/B-Spanish.jpg 2000w, https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/06\/B-Spanish-300x164.jpg 300w, https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/06\/B-Spanish-1024x561.jpg 1024w, https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/06\/B-Spanish-768x421.jpg 768w, https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/06\/B-Spanish-1536x842.jpg 1536w\" sizes=\"(max-width: 2000px) 100vw, 2000px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-04a024e screen-reader-text elementor-widget elementor-widget-text-editor\" data-id=\"04a024e\" data-element_type=\"widget\" data-e-type=\"widget\" id=\"transporter\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>Transportador (vector v\u00edrico adenoasociado, VAA)<\/h3>\n<ol>\n<li>El ADN v\u00edrico se elimina<\/li>\n<li>Se inserta el gen <em>IDS<\/em> humano funcional<\/li>\n<li>El tratamiento se administra en el sistema nervioso central, guiado por una tomograf\u00eda computadorizada mientras el paciente est\u00e1 dormido<\/li>\n<li>El vector se une a la membrana celular<\/li>\n<li>El vector se internaliza mediante una ves\u00edcula en una c\u00e9lula (una peque\u00f1a bolsa de l\u00edquido) y se transporta al n\u00facleo<\/li>\n<li>El vector libera el gen funcional en el n\u00facleo<\/li>\n<li>La c\u00e9lula produce una enzima ausente del gen sano<\/li>\n<li>El complemento enzim\u00e1tico completo puede ahora descomponer los GAG que de otro modo se acumular\u00edan en personas con MPS II<\/li>\n<li>La enzima resultante es segregada y absorbida por otras c\u00e9lulas<\/li>\n<\/ol>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-816d0ab elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"816d0ab\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>RGX-121 ha recibido designaciones de Orphan Drug Product, Rare Pediatric Disease y Fast Track de la Administraci\u00f3n de Alimentos y Medicamentos (FDA) de los EE. UU., as\u00ed como la designaci\u00f3n del f\u00e1rmaco Orphan por parte de la Agencia Europea de Medicamentos (EMA).<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a8e9c5c references elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"a8e9c5c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>Referencias<\/h3>\n<ol>\n<li>Different approaches. American Society of Gene + Cell Therapy; 2022. <a href=\"https:\/\/patienteducation.asgct.org\/gene-therapy-101\/different-approaches\" target=\"_blank\" rel=\"noopener\">https:\/\/patienteducation.asgct.org\/gene-therapy-101\/different-approaches<\/a>. <\/li>\n<li>Petrich J, Marchese D, Jenkins C, Storey M, Blind J. Gene replacement therapy: a primer for the health-system pharmacist. sJ Pharm Pract. 2020;33(6):846-855. <\/li>\n<li>Adachi H, Hengesbach M, Yu Y-T, Morais P. From antisense RNA to RNA modification: therapeutic potential of RNA-based technologies. Biomedicines. 2021;9(5):550. <\/li>\n<li>Pukenas B, Papisov M, Buss N, et al. Intracisternal administration of AAV9 gene therapies to target the central nervous system. Presented at WORLD<em>Symposium<\/em>\u2122 2021 Virtual Scientific Meeting, February 9, 2021, Poster #207. <\/li>\n<\/ol>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-51c5af4 elementor-section-stretched light-green-row elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"51c5af4\" data-element_type=\"section\" data-e-type=\"section\" id=\"campsiite-study\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-89e45fb\" data-id=\"89e45fb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4c96548 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"4c96548\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>Estudio CAMPSIITE\u2122<\/h2>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-096883b elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"096883b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>Descripci\u00f3n general del ensayo<\/h3>\n<p>Actualmente estamos inscribiendo a ni\u00f1os con s\u00edndrome de Hunter <strong>neuronop\u00e1tico<\/strong> (MPS II) mayores de 4 meses y menores de 5 a\u00f1os en el estudio CAMPSIITE\u2122, que es un estudio multic\u00e9ntrico, abierto y de un solo grupo de fase I\/II\/III de RGX-121.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d1bbec elementor-widget-divider--view-line elementor-invisible elementor-widget elementor-widget-divider\" data-id=\"4d1bbec\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;,&quot;_animation_delay&quot;:150}\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea9640d elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"ea9640d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>Participaci\u00f3n en CAMPSIITE<\/h3>\n<p>Si a su hijo se le ha diagnosticado MPS II y su familia est\u00e1 interesada en participar en el estudio CAMPSIITE, hable con el m\u00e9dico que trata su MPS II o p\u00f3ngase en contacto con uno de los centros del estudio. CAMPSIITE es un ensayo a nivel mundial que se espera que incluya centros en Estados Unidos, Brasil y Canad\u00e1. <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2877502 what-to-expect-map elementor-widget elementor-widget-html\" data-id=\"2877502\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"title-img-wrap\">\n    <h4><img decoding=\"async\" src=\"\/wp-content\/uploads\/2023\/06\/title-es-1.svg\" alt=\"Qu\u00e9 esperar\"><\/h4>\n<\/div>\n<div class=\"process-step initial-meeting\">\n    <h5>Reuni\u00f3n inicial con el m\u00e9dico del estudio<\/h5>\n    <p>Los padres de ni\u00f1os que puedan ser elegibles deber\u00e1n reunirse con un m\u00e9dico del estudio para revisar los detalles del estudio y el proceso de consentimiento informado.<\/p>\n<\/div>\n<div class=\"process-step determine-eligibility\">\n    <h5>Determinar elegibilidad<\/h5>\n    <p>El m\u00e9dico y el equipo del estudio comentar\u00e1n con usted sobre la salud de su hijo, la informaci\u00f3n b\u00e1sica sobre el estudio y posiblemente solicitar\u00e1n su historia cl\u00ednica.<\/p>\n<\/div>\n<div class=\"process-step if-eligible\">\n    <h5>Si es elegible y decide inscribir a su hijo<\/h5>\n    <p>Si parece que su hijo puede calificar, el equipo del estudio puede programar una visita de selecci\u00f3n inicial para comenzar a determinar la elegibilidad y revisar el formulario de consentimiento informado con usted en detalle. El proceso de determinaci\u00f3n de la elegibilidad puede tardar unas semanas. <\/p>\n<\/div>\n<div class=\"process-step study-duration\">\n    <h5>Duraci\u00f3n del estudio principal<\/h5>\n    <p>Si su hijo cumple los requisitos <em>y<\/em> usted decide inscribirle en el estudio, la participaci\u00f3n en la parte principal del estudio durar\u00e1 unos 2 a\u00f1os. Durante este tiempo, su hijo acudir\u00e1 a la cl\u00ednica varias veces al a\u00f1o para varias pruebas y evaluaciones. <\/p>\n<\/div>\n<div class=\"process-step follow-up\">\n    <h5>Seguimiento de largo plazo<\/h5>\n    <p>Al final del estudio principal, se animar\u00e1 a su hijo a inscribirse en un estudio de seguimiento a largo plazo, que tiene como objetivo comprender la seguridad y eficacia a largo plazo de RGX-121.<\/p>\n<\/div>\n<div class=\"map-bg\">\n    <svg id=\"eMPFgTbyUiR1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" viewBox=\"0 0 1121 866\" shape-rendering=\"geometricPrecision\" text-rendering=\"geometricPrecision\"><defs><polygon id=\"eMPFgTbyUiR3\" points=\"0,0 72.501621,0 72.501621,73.365635 0,73.365635\"\/><\/defs><g transform=\"translate(.281189-.855713)\"><g transform=\"translate(0 2.5)\"><g transform=\"translate(0 762.5)\"><path d=\"M120.616649,18.027719c-1.518856,0-2.994656.177636-4.413046.503628C111.95635,12.758174,105.063842,9,97.277541,9C87.657626,9,79.398694,14.732668,75.81362,22.921007C67.035039,23.184533,60,30.279728,60,39h79.907453c.059883-.611966.092547-1.23174.092547-1.858835c0-10.55617-8.678115-19.113446-19.383351-19.113446Z\" fill=\"#fff\" fill-rule=\"evenodd\"\/><g><g transform=\"translate(0 26.5306)\"><polygon points=\"25.714286,0 16.187113,15.766192 20.9507,15.766192 7.598737,40.938193 13.46273,40.938193 0,66.326531 25.714286,66.326531 25.714286,40.938193 25.714286,15.766192\" fill=\"#8ce969\" fill-rule=\"evenodd\"\/><polygon points=\"25.306122,15.76605 25.306122,40.938422 25.306122,66.326531 51.020408,66.326531 37.557679,40.938422 43.421671,40.938422 30.069709,15.76605 34.833295,15.76605 25.306122,0\" fill=\"#78be21\" fill-rule=\"evenodd\"\/><\/g><g transform=\"translate(23.4694 0)\"><polygon points=\"38.571429,0 24.28067,23.770566 31.426049,23.770566 11.398106,61.722199 20.194094,61.722199 0,100 38.571429,100 38.571429,61.722199 38.571429,23.770566\" fill=\"#8ce969\" fill-rule=\"evenodd\"\/><polygon points=\"37.959184,23.770352 37.959184,61.722544 37.959184,100 76.530612,100 56.336518,61.722544 65.132507,61.722544 45.104563,23.770352 52.249942,23.770352 37.959184,0\" fill=\"#78be21\" fill-rule=\"evenodd\"\/><\/g><\/g><\/g><g transform=\"translate(736 629.5)\"><path d=\"M244.546703,87.237613c0-32.724128-26.527557-59.251684-59.251684-59.251684-4.64289,0-9.154163.550672-13.489947,1.561245C158.821925,11.65034,137.752676,0,113.951248,0C84.544767,0,59.298582,17.771269,48.339607,43.155123C21.504945,43.972053,0,65.967157,0,93h244.263803c.183053-1.897095.2829-3.818395.2829-5.762387\" fill=\"#fff\" fill-rule=\"evenodd\"\/><g transform=\"translate(94 12.2114)\"><g transform=\"translate(132.267 92.1284)\"><polygon points=\"37.988586,0 23.913772,23.228856 30.951179,23.228856 11.225872,60.315605 19.888947,60.315605 0,97.721088 37.988586,97.721088 37.988586,60.315605 37.988586,23.228856\" fill=\"#8ce969\" fill-rule=\"evenodd\"\/><polygon points=\"37.385593,23.228646 37.385593,60.315942 37.385593,97.721088 75.374179,97.721088 55.485232,60.315942 64.148307,60.315942 44.423,23.228646 51.460407,23.228646 37.385593,0\" fill=\"#78be21\" fill-rule=\"evenodd\"\/><\/g><g transform=\"translate(166.939 53.04)\"><polygon points=\"56.982879,0 35.870658,35.021967 46.426768,35.021967 16.838808,90.937374 29.833421,90.937374 0,147.333333 56.982879,147.333333 56.982879,90.937374 56.982879,35.021967\" fill=\"#8ce969\" fill-rule=\"evenodd\"\/><polygon points=\"56.078389,35.021651 56.078389,90.937882 56.078389,147.333333 113.061268,147.333333 83.227848,90.937882 96.222461,90.937882 66.6345,35.021651 77.190611,35.021651 56.078389,0\" fill=\"#78be21\" fill-rule=\"evenodd\"\/><\/g><g><polygon points=\"85.626273,0 53.901641,52.53295 69.763957,52.53295 25.303115,136.40606 44.829687,136.40606 0,221 85.626273,221 85.626273,136.40606 85.626273,52.53295\" fill=\"#8ce969\" fill-rule=\"evenodd\"\/><polygon points=\"84.267126,52.532477 84.267126,136.406822 84.267126,221 169.893399,221 125.063713,136.406822 144.590284,136.406822 100.129442,52.532477 115.991758,52.532477 84.267126,0\" fill=\"#78be21\" fill-rule=\"evenodd\"\/><\/g><\/g><\/g><path d=\"M1120.4376,165.914768c0-42.754489-34.66028-77.414768-77.41477-77.414768-29.25502,0-54.712358,16.233478-67.877117,40.178181-4.98848-1.654244-10.318107-2.563435-15.863366-2.563435-27.826061,0-50.383644,22.557583-50.383644,50.385254h210.800277c.4731-3.46297.73862-6.991917.73862-10.585232\" fill=\"#fff\" fill-rule=\"evenodd\"\/><path id=\"eMPFgTbyUiR28\" d=\"M552.5,0v166.675058c0,8.836556,7.163444,16,16,16h92.5c8.836556,0,16,7.163444,16,16L677,241.5v0\" fill=\"none\" fill-rule=\"evenodd\" stroke=\"#007f01\" stroke-width=\"4\" stroke-linecap=\"square\" stroke-dashoffset=\"352.27\" stroke-dasharray=\"352.27\"\/><line id=\"eMPFgTbyUiR29\" x1=\"677\" y1=\"430.000002\" x2=\"677\" y2=\"241.5\" fill=\"none\" fill-rule=\"evenodd\" stroke=\"#007f01\" stroke-width=\"4\" stroke-linecap=\"square\" stroke-dashoffset=\"188.5\" stroke-dasharray=\"188.5\"\/><path id=\"eMPFgTbyUiR30\" d=\"M2.5,198.5v0-90.1c0-8.8,7.2-16,16-16h146.6c8.8,0,16-7.2,16-16v-57.8c0-8.8,7.2-16,16-16h85.8c8.8,0,16,7.2,16,16v37.3c0,8.8,7.2,16,16,16h228.6\" transform=\"translate(133.498811 360.165713)\" fill=\"none\" stroke=\"#007f01\" stroke-width=\"4\" stroke-linecap=\"square\" stroke-dashoffset=\"771.802051\" stroke-dasharray=\"771.802051\"\/><path id=\"eMPFgTbyUiR31\" d=\"M136,564v189.5c0,8.836556,7.163444,16,16,16h196v0\" fill=\"none\" fill-rule=\"evenodd\" stroke=\"#007f01\" stroke-width=\"4\" stroke-linecap=\"square\" stroke-dashoffset=\"410.64\" stroke-dasharray=\"410.64\"\/><g transform=\"translate(62 271.5)\"><polygon points=\"52.997977,0 33.515985,32.244616 44.908105,32.244616 15.850117,84.87165 29.553362,84.87165 0,137.999962 52.997977,137.999962\" fill=\"#70e000\" fill-rule=\"evenodd\"\/><polygon points=\"52.997977,0 52.997977,137.999962 105.996327,137.999962 76.442592,84.87165 90.14621,84.87165 61.088222,32.244616 72.479969,32.244616\" fill=\"#54a800\" fill-rule=\"evenodd\"\/><g transform=\"translate(26.8729 0.000038)\"><g transform=\"translate(80.4323 0)\"><g mask=\"url(#eMPFgTbyUiR39)\"><path d=\"M72.501621,36.682798c0-20.25927-16.230141-36.682836-36.250811-36.682836s-36.25081,16.423566-36.25081,36.682836s16.230141,36.682837,36.25081,36.682837s36.250811-16.423567,36.250811-36.682837\" fill=\"#f9461c\" fill-rule=\"evenodd\"\/><mask id=\"eMPFgTbyUiR39\" mask-type=\"luminance\"><use width=\"72.501617\" height=\"73.365631\" xlink:href=\"#eMPFgTbyUiR3\" fill=\"#fff\" fill-rule=\"evenodd\"\/><\/mask><\/g><\/g><polygon points=\"173.127148,137.999433 123.832347,137.999433 61.916136,35.11841 111.210937,35.11841\" fill=\"#0065bd\" fill-rule=\"evenodd\"\/><polygon points=\"123.832422,137.999433 0,137.999433 61.916211,35.11841\" fill=\"#00a9e0\" fill-rule=\"evenodd\"\/><polygon points=\"61.916211,88.99218 32.422204,137.999962 61.916211,137.999962 91.410218,137.999962\" fill=\"#00335f\" fill-rule=\"evenodd\"\/><\/g><\/g><g transform=\"translate(508 473.5)\"><path d=\"M17.544963,42h-9.206764c4.495875-15.890052,7.295531-30.698171,4.603382-42c3.264026,9.201607,4.058382,25.254467,4.603382,42\" fill=\"#70e000\" fill-rule=\"evenodd\"\/><path d=\"M8.337751,42L0,42C4.073314,27.610741,4.094218,17.453008,1.655904,7.218311C4.610848,15.549635,7.843518,26.836664,8.337751,42\" fill=\"#70e000\" fill-rule=\"evenodd\"\/><path d=\"M5.56736,42h8.149613c-3.250587-11.488318-5.275299-22.193678-3.328231-30.365155C8.029564,18.287768,5.961551,29.893012,5.56736,42\" fill=\"#54a800\" fill-rule=\"evenodd\"\/><path d=\"M15.832469,42h6.656463C19.238344,30.511682,19.916234,28.383339,24,22.722064C18.290194,27.726187,16.22666,29.893012,15.832469,42\" fill=\"#54a800\" fill-rule=\"evenodd\"\/><\/g><g transform=\"translate(460 486.5)\"><path d=\"M17.544963,42h-9.206764c4.495875-15.890052,7.295531-30.698171,4.603382-42c3.264026,9.201607,4.058382,25.254467,4.603382,42\" fill=\"#70e000\" fill-rule=\"evenodd\"\/><path d=\"M8.337751,42L0,42C4.073314,27.610741,4.094218,17.453008,1.655904,7.218311C4.610848,15.549635,7.843518,26.836664,8.337751,42\" fill=\"#70e000\" fill-rule=\"evenodd\"\/><path d=\"M5.56736,42h8.149613c-3.250587-11.488318-5.275299-22.193678-3.328231-30.365155C8.029564,18.287768,5.961551,29.893012,5.56736,42\" fill=\"#54a800\" fill-rule=\"evenodd\"\/><path d=\"M15.832469,42h6.656463C19.238344,30.511682,19.916234,28.383339,24,22.722064C18.290194,27.726187,16.22666,29.893012,15.832469,42\" fill=\"#54a800\" fill-rule=\"evenodd\"\/><\/g><g transform=\"translate(396 473.5)\"><path d=\"M17.544963,42h-9.206764c4.495875-15.890052,7.295531-30.698171,4.603382-42c3.264026,9.201607,4.058382,25.254467,4.603382,42\" fill=\"#70e000\" fill-rule=\"evenodd\"\/><path d=\"M8.337751,42L0,42C4.073314,27.610741,4.094218,17.453008,1.655904,7.218311C4.610848,15.549635,7.843518,26.836664,8.337751,42\" fill=\"#70e000\" fill-rule=\"evenodd\"\/><path d=\"M5.56736,42h8.149613c-3.250587-11.488318-5.275299-22.193678-3.328231-30.365155C8.029564,18.287768,5.961551,29.893012,5.56736,42\" fill=\"#54a800\" fill-rule=\"evenodd\"\/><path d=\"M15.832469,42h6.656463C19.238344,30.511682,19.916234,28.383339,24,22.722064C18.290194,27.726187,16.22666,29.893012,15.832469,42\" fill=\"#54a800\" fill-rule=\"evenodd\"\/><\/g><g transform=\"translate(487 273.5)\"><g transform=\"translate(46 0)\"><polygon points=\"50.4,0 31.726743,30.901735 41.063371,30.901735 14.893525,80.238859 26.38695,80.238859 0,130 50.4,130 50.4,80.238859 50.4,30.901735\" fill=\"#8ce969\" fill-rule=\"evenodd\"\/><polygon points=\"49.6,30.901457 49.6,80.239307 49.6,130 100,130 73.61305,80.239307 85.106476,80.239307 58.936629,30.901457 68.273258,30.901457 49.6,0\" fill=\"#78be21\" fill-rule=\"evenodd\"\/><\/g><g transform=\"translate(12 27)\"><polygon points=\"37.105526,108 42.896711,108 42.896711,0 37.105526,0\" fill=\"#007f01\" fill-rule=\"evenodd\"\/><polygon points=\"11.160124,7.350593 11.160124,30.495456 68.811912,30.495456 80,18.92162 68.811912,7.350593\" fill=\"#007f01\" fill-rule=\"evenodd\"\/><polygon points=\"11.185291,36.295289 0,47.869124 11.185291,59.440152 68.839876,59.440152 68.839876,36.295289\" fill=\"#007f01\" fill-rule=\"evenodd\"\/><\/g><g transform=\"translate(0 93)\"><path d=\"M17.544963,42h-9.206764c4.495875-15.890052,7.295531-30.698171,4.603382-42c3.264026,9.201607,4.058382,25.254467,4.603382,42\" fill=\"#70e000\" fill-rule=\"evenodd\"\/><path d=\"M8.337751,42L0,42C4.073314,27.610741,4.094218,17.453008,1.655904,7.218311C4.610848,15.549635,7.843518,26.836664,8.337751,42\" fill=\"#70e000\" fill-rule=\"evenodd\"\/><path d=\"M5.56736,42h8.149613c-3.250587-11.488318-5.275299-22.193678-3.328231-30.365155C8.029564,18.287768,5.961551,29.893012,5.56736,42\" fill=\"#54a800\" fill-rule=\"evenodd\"\/><path d=\"M15.832469,42h6.656463C19.238344,30.511682,19.916234,28.383339,24,22.722064C18.290194,27.726187,16.22666,29.893012,15.832469,42\" fill=\"#54a800\" fill-rule=\"evenodd\"\/><\/g><\/g><\/g><\/g><script>!function(t,e){\"object\"==typeof exports&&\"undefined\"!=typeof module?module.exports=e():\"function\"==typeof define&&define.amd?define(e):((t=\"undefined\"!=typeof globalThis?globalThis:t||self).__SVGATOR_PLAYER__=t.__SVGATOR_PLAYER__||{},t.__SVGATOR_PLAYER__&#091;\"91c80d77\"&#093;=e())}(this,(function(){\"use strict\";function t(t,e){var n=Object.keys(t);if(Object.getOwnPropertySymbols){var r=Object.getOwnPropertySymbols(t);e&&(r=r.filter((function(e){return Object.getOwnPropertyDescriptor(t,e).enumerable}))),n.push.apply(n,r)}return n}function e(e){for(var n=1;n&#60;arguments.length;n++){var r=null!=arguments&#091;n&#093;?arguments&#091;n&#093;:{};n%2?t(Object(r),!0).forEach((function(t){u(e,t,r&#091;t&#093;)})):Object.getOwnPropertyDescriptors?Object.defineProperties(e,Object.getOwnPropertyDescriptors(r)):t(Object(r)).forEach((function(t){Object.defineProperty(e,t,Object.getOwnPropertyDescriptor(r,t))}))}return e}function n(t){return(n=\"function\"==typeof Symbol&&\"symbol\"==typeof Symbol.iterator?function(t){return typeof t}:function(t){return t&&\"function\"==typeof Symbol&&t.constructor===Symbol&&t!==Symbol.prototype?\"symbol\":typeof t})(t)}function r(t,e){if(!(t instanceof e))throw new TypeError(\"Cannot call a class as a function\")}function i(t,e){for(var n=0;n&#60;e.length;n++){var r=e&#091;n&#093;;r.enumerable=r.enumerable||!1,r.configurable=!0,\"value\"in r&&(r.writable=!0),Object.defineProperty(t,r.key,r)}}function o(t,e,n){return e&&i(t.prototype,e),n&&i(t,n),t}function u(t,e,n){return e in t?Object.defineProperty(t,e,{value:n,enumerable:!0,configurable:!0,writable:!0}):t&#091;e&#093;=n,t}function a(t){return(a=Object.setPrototypeOf?Object.getPrototypeOf:function(t){return t.__proto__||Object.getPrototypeOf(t)})(t)}function s(t,e){return(s=Object.setPrototypeOf||function(t,e){return t.__proto__=e,t})(t,e)}function l(){if(\"undefined\"==typeof Reflect||!Reflect.construct)return!1;if(Reflect.construct.sham)return!1;if(\"function\"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Reflect.construct(Boolean,&#091;&#093;,(function(){}))),!0}catch(t){return!1}}function f(t,e,n){return(f=l()?Reflect.construct:function(t,e,n){var r=&#091;null&#093;;r.push.apply(r,e);var i=new(Function.bind.apply(t,r));return n&&s(i,n.prototype),i}).apply(null,arguments)}function c(t,e){if(e&&(\"object\"==typeof e||\"function\"==typeof e))return e;if(void 0!==e)throw new TypeError(\"Derived constructors may only return object or undefined\");return function(t){if(void 0===t)throw new ReferenceError(\"this hasn't been initialised - super() hasn't been called\");return t}(t)}function h(t,e,n){return(h=\"undefined\"!=typeof Reflect&&Reflect.get?Reflect.get:function(t,e,n){var r=function(t,e){for(;!Object.prototype.hasOwnProperty.call(t,e)&&null!==(t=a(t)););return t}(t,e);if(r){var i=Object.getOwnPropertyDescriptor(r,e);return i.get?i.get.call(n):i.value}})(t,e,n||t)}function v(t){return function(t){if(Array.isArray(t))return y(t)}(t)||function(t){if(\"undefined\"!=typeof Symbol&&null!=t&#091;Symbol.iterator&#093;||null!=t&#091;\"@@iterator\"&#093;)return Array.from(t)}(t)||function(t,e){if(!t)return;if(\"string\"==typeof t)return y(t,e);var n=Object.prototype.toString.call(t).slice(8,-1);\"Object\"===n&&t.constructor&&(n=t.constructor.name);if(\"Map\"===n||\"Set\"===n)return Array.from(t);if(\"Arguments\"===n||\/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$\/.test(n))return y(t,e)}(t)||function(){throw new TypeError(\"Invalid attempt to spread non-iterable instance.\\nIn order to be iterable, non-array objects must have a &#091;Symbol.iterator&#093;() method.\")}()}function y(t,e){(null==e||e&#62;t.length)&&(e=t.length);for(var n=0,r=new Array(e);n&#60;e;n++)r&#091;n&#093;=t&#091;n&#093;;return r}Number.isInteger||(Number.isInteger=function(t){return\"number\"==typeof t&&isFinite(t)&&Math.floor(t)===t}),Number.EPSILON||(Number.EPSILON=2220446049250313e-31);var d=g(Math.pow(10,-6));function g(t){var e=arguments.length&#62;1&&void 0!==arguments&#091;1&#093;?arguments&#091;1&#093;:6;if(Number.isInteger(t))return t;var n=Math.pow(10,e);return Math.round((+t+Number.EPSILON)*n)\/n}function p(t,e){var n=arguments.length&#62;2&&void 0!==arguments&#091;2&#093;?arguments&#091;2&#093;:d;return Math.abs(t-e)&#60;n}var m=Math.PI\/180;function b(t){return t}function k(t,e,n){var r=1-n;return 3*n*r*(t*r+e*n)+n*n*n}function w(){var t=arguments.length&#62;0&&void 0!==arguments&#091;0&#093;?arguments&#091;0&#093;:0,e=arguments.length&#62;1&&void 0!==arguments&#091;1&#093;?arguments&#091;1&#093;:0,n=arguments.length&#62;2&&void 0!==arguments&#091;2&#093;?arguments&#091;2&#093;:1,r=arguments.length&#62;3&&void 0!==arguments&#091;3&#093;?arguments&#091;3&#093;:1;return t&#60;0||t&#62;1||n&#60;0||n&#62;1?null:p(t,e)&&p(n,r)?b:function(i){if(i&#60;=0)return t&#62;0?i*e\/t:0===e&&n&#62;0?i*r\/n:0;if(i&#62;=1)return n&#60;1?1+(i-1)*(r-1)\/(n-1):1===n&&t&#60;1?1+(i-1)*(e-1)\/(t-1):1;for(var o,u=0,a=1;u&#60;a;){var s=k(t,n,o=(u+a)\/2);if(p(i,s))break;s&#60;i?u=o:a=o}return k(e,r,o)}}function x(){return 1}function A(t){return 1===t?1:0}function _(){var t=arguments.length&#62;0&&void 0!==arguments&#091;0&#093;?arguments&#091;0&#093;:1,e=arguments.length&#62;1&&void 0!==arguments&#091;1&#093;?arguments&#091;1&#093;:0;if(1===t){if(0===e)return A;if(1===e)return x}var n=1\/t;return function(t){return t&#62;=1?1:(t+=e*n)-t%n}}var O=Math.sin,S=Math.cos,E=Math.acos,P=Math.asin,M=Math.tan,j=Math.atan2,B=Math.PI\/180,T=180\/Math.PI,I=Math.sqrt,R=function(){function t(){var e=arguments.length&#62;0&&void 0!==arguments&#091;0&#093;?arguments&#091;0&#093;:1,n=arguments.length&#62;1&&void 0!==arguments&#091;1&#093;?arguments&#091;1&#093;:0,i=arguments.length&#62;2&&void 0!==arguments&#091;2&#093;?arguments&#091;2&#093;:0,o=arguments.length&#62;3&&void 0!==arguments&#091;3&#093;?arguments&#091;3&#093;:1,u=arguments.length&#62;4&&void 0!==arguments&#091;4&#093;?arguments&#091;4&#093;:0,a=arguments.length&#62;5&&void 0!==arguments&#091;5&#093;?arguments&#091;5&#093;:0;r(this,t),this.m=&#091;e,n,i,o,u,a&#093;,this.i=null,this.w=null,this.s=null}return o(t,&#091;{key:\"determinant\",get:function(){var t=this.m;return t&#091;0&#093;*t&#091;3&#093;-t&#091;1&#093;*t&#091;2&#093;}},{key:\"isIdentity\",get:function(){if(null===this.i){var t=this.m;this.i=1===t&#091;0&#093;&&0===t&#091;1&#093;&&0===t&#091;2&#093;&&1===t&#091;3&#093;&&0===t&#091;4&#093;&&0===t&#091;5&#093;}return this.i}},{key:\"point\",value:function(t,e){var n=this.m;return{x:n&#091;0&#093;*t+n&#091;2&#093;*e+n&#091;4&#093;,y:n&#091;1&#093;*t+n&#091;3&#093;*e+n&#091;5&#093;}}},{key:\"translateSelf\",value:function(){var t=arguments.length&#62;0&&void 0!==arguments&#091;0&#093;?arguments&#091;0&#093;:0,e=arguments.length&#62;1&&void 0!==arguments&#091;1&#093;?arguments&#091;1&#093;:0;if(!t&&!e)return this;var n=this.m;return n&#091;4&#093;+=n&#091;0&#093;*t+n&#091;2&#093;*e,n&#091;5&#093;+=n&#091;1&#093;*t+n&#091;3&#093;*e,this.w=this.s=this.i=null,this}},{key:\"rotateSelf\",value:function(){var t=arguments.length&#62;0&&void 0!==arguments&#091;0&#093;?arguments&#091;0&#093;:0;if(t%=360){var e=O(t*=B),n=S(t),r=this.m,i=r&#091;0&#093;,o=r&#091;1&#093;;r&#091;0&#093;=i*n+r&#091;2&#093;*e,r&#091;1&#093;=o*n+r&#091;3&#093;*e,r&#091;2&#093;=r&#091;2&#093;*n-i*e,r&#091;3&#093;=r&#091;3&#093;*n-o*e,this.w=this.s=this.i=null}return this}},{key:\"scaleSelf\",value:function(){var t=arguments.length&#62;0&&void 0!==arguments&#091;0&#093;?arguments&#091;0&#093;:1,e=arguments.length&#62;1&&void 0!==arguments&#091;1&#093;?arguments&#091;1&#093;:1;if(1!==t||1!==e){var n=this.m;n&#091;0&#093;*=t,n&#091;1&#093;*=t,n&#091;2&#093;*=e,n&#091;3&#093;*=e,this.w=this.s=this.i=null}return this}},{key:\"skewSelf\",value:function(t,e){if(e%=360,(t%=360)||e){var n=this.m,r=n&#091;0&#093;,i=n&#091;1&#093;,o=n&#091;2&#093;,u=n&#091;3&#093;;t&&(t=M(t*B),n&#091;2&#093;+=r*t,n&#091;3&#093;+=i*t),e&&(e=M(e*B),n&#091;0&#093;+=o*e,n&#091;1&#093;+=u*e),this.w=this.s=this.i=null}return this}},{key:\"resetSelf\",value:function(){var t=arguments.length&#62;0&&void 0!==arguments&#091;0&#093;?arguments&#091;0&#093;:1,e=arguments.length&#62;1&&void 0!==arguments&#091;1&#093;?arguments&#091;1&#093;:0,n=arguments.length&#62;2&&void 0!==arguments&#091;2&#093;?arguments&#091;2&#093;:0,r=arguments.length&#62;3&&void 0!==arguments&#091;3&#093;?arguments&#091;3&#093;:1,i=arguments.length&#62;4&&void 0!==arguments&#091;4&#093;?arguments&#091;4&#093;:0,o=arguments.length&#62;5&&void 0!==arguments&#091;5&#093;?arguments&#091;5&#093;:0,u=this.m;return u&#091;0&#093;=t,u&#091;1&#093;=e,u&#091;2&#093;=n,u&#091;3&#093;=r,u&#091;4&#093;=i,u&#091;5&#093;=o,this.w=this.s=this.i=null,this}},{key:\"recomposeSelf\",value:function(){var t=arguments.length&#62;0&&void 0!==arguments&#091;0&#093;?arguments&#091;0&#093;:null,e=arguments.length&#62;1&&void 0!==arguments&#091;1&#093;?arguments&#091;1&#093;:null,n=arguments.length&#62;2&&void 0!==arguments&#091;2&#093;?arguments&#091;2&#093;:null,r=arguments.length&#62;3&&void 0!==arguments&#091;3&#093;?arguments&#091;3&#093;:null,i=arguments.length&#62;4&&void 0!==arguments&#091;4&#093;?arguments&#091;4&#093;:null;return this.isIdentity||this.resetSelf(),t&&(t.x||t.y)&&this.translateSelf(t.x,t.y),e&&this.rotateSelf(e),n&&(n.x&&this.skewSelf(n.x,0),n.y&&this.skewSelf(0,n.y)),!r||1===r.x&&1===r.y||this.scaleSelf(r.x,r.y),i&&(i.x||i.y)&&this.translateSelf(i.x,i.y),this}},{key:\"decompose\",value:function(){var t=arguments.length&#62;0&&void 0!==arguments&#091;0&#093;?arguments&#091;0&#093;:0,e=arguments.length&#62;1&&void 0!==arguments&#091;1&#093;?arguments&#091;1&#093;:0,n=this.m,r=n&#091;0&#093;*n&#091;0&#093;+n&#091;1&#093;*n&#091;1&#093;,i=&#091;&#091;n&#091;0&#093;,n&#091;1&#093;&#093;,&#091;n&#091;2&#093;,n&#091;3&#093;&#093;&#093;,o=I(r);if(0===o)return{origin:{x:g(n&#091;4&#093;),y:g(n&#091;5&#093;)},translate:{x:g(t),y:g(e)},scale:{x:0,y:0},skew:{x:0,y:0},rotate:0};i&#091;0&#093;&#091;0&#093;\/=o,i&#091;0&#093;&#091;1&#093;\/=o;var u=n&#091;0&#093;*n&#091;3&#093;-n&#091;1&#093;*n&#091;2&#093;&#60;0;u&&(o=-o);var a=i&#091;0&#093;&#091;0&#093;*i&#091;1&#093;&#091;0&#093;+i&#091;0&#093;&#091;1&#093;*i&#091;1&#093;&#091;1&#093;;i&#091;1&#093;&#091;0&#093;-=i&#091;0&#093;&#091;0&#093;*a,i&#091;1&#093;&#091;1&#093;-=i&#091;0&#093;&#091;1&#093;*a;var s=I(i&#091;1&#093;&#091;0&#093;*i&#091;1&#093;&#091;0&#093;+i&#091;1&#093;&#091;1&#093;*i&#091;1&#093;&#091;1&#093;);if(0===s)return{origin:{x:g(n&#091;4&#093;),y:g(n&#091;5&#093;)},translate:{x:g(t),y:g(e)},scale:{x:g(o),y:0},skew:{x:0,y:0},rotate:0};i&#091;1&#093;&#091;0&#093;\/=s,i&#091;1&#093;&#091;1&#093;\/=s,a\/=s;var l=0;return i&#091;1&#093;&#091;1&#093;&#60;0?(l=E(i&#091;1&#093;&#091;1&#093;)*T,i&#091;0&#093;&#091;1&#093;&#60;0&&(l=360-l)):l=P(i&#091;0&#093;&#091;1&#093;)*T,u&&(l=-l),a=j(a,I(i&#091;0&#093;&#091;0&#093;*i&#091;0&#093;&#091;0&#093;+i&#091;0&#093;&#091;1&#093;*i&#091;0&#093;&#091;1&#093;))*T,u&&(a=-a),{origin:{x:g(n&#091;4&#093;),y:g(n&#091;5&#093;)},translate:{x:g(t),y:g(e)},scale:{x:g(o),y:g(s)},skew:{x:g(a),y:0},rotate:g(l)}}},{key:\"clone\",value:function(){var t=this.m;return new this.constructor(t&#091;0&#093;,t&#091;1&#093;,t&#091;2&#093;,t&#091;3&#093;,t&#091;4&#093;,t&#091;5&#093;)}},{key:\"toString\",value:function(){var t=arguments.length&#62;0&&void 0!==arguments&#091;0&#093;?arguments&#091;0&#093;:\" \";if(null===this.s){var e=this.m.map((function(t){return g(t)}));1===e&#091;0&#093;&&0===e&#091;1&#093;&&0===e&#091;2&#093;&&1===e&#091;3&#093;?this.s=\"translate(\"+e&#091;4&#093;+t+e&#091;5&#093;+\")\":this.s=\"matrix(\"+e.join(t)+\")\"}return this.s}}&#093;,&#091;{key:\"create\",value:function(t){return t?Array.isArray(t)?f(this,v(t)):t instanceof this?t.clone():(new this).recomposeSelf(t.origin,t.rotate,t.skew,t.scale,t.translate):new this}}&#093;),t}();function N(t,e,n){return t&#62;=.5?n:e}function F(t,e,n){return 0===t||e===n?e:t*(n-e)+e}function C(t,e,n){var r=F(t,e,n);return r&#60;=0?0:r}function L(t,e,n){var r=F(t,e,n);return r&#60;=0?0:r&#62;=1?1:r}function D(t,e,n){return 0===t?e:1===t?n:{x:F(t,e.x,n.x),y:F(t,e.y,n.y)}}function q(t,e,n){return 0===t?e:1===t?n:{x:C(t,e.x,n.x),y:C(t,e.y,n.y)}}function V(t,e,n){var r=function(t,e,n){return Math.round(F(t,e,n))}(t,e,n);return r&#60;=0?0:r&#62;=255?255:r}function z(t,e,n){return 0===t?e:1===t?n:{r:V(t,e.r,n.r),g:V(t,e.g,n.g),b:V(t,e.b,n.b),a:F(t,null==e.a?1:e.a,null==n.a?1:n.a)}}function Y(t,e,n){var r=e.length;if(r!==n.length)return N(t,e,n);for(var i=new Array(r),o=0;o&#60;r;o++)i&#091;o&#093;=F(t,e&#091;o&#093;,n&#091;o&#093;);return i}function G(t,e){for(var n=&#091;&#093;,r=0;r&#60;t;r++)n.push(e);return n}function U(t,e){if(--e&#60;=0)return t;var n=(t=Object.assign(&#091;&#093;,t)).length;do{for(var r=0;r&#60;n;r++)t.push(t&#091;r&#093;)}while(--e&#62;0);return t}var $,W=function(){function t(e){r(this,t),this.list=e,this.length=e.length}return o(t,&#091;{key:\"setAttribute\",value:function(t,e){for(var n=this.list,r=0;r&#60;this.length;r++)n&#091;r&#093;.setAttribute(t,e)}},{key:\"removeAttribute\",value:function(t){for(var e=this.list,n=0;n&#60;this.length;n++)e&#091;n&#093;.removeAttribute(t)}},{key:\"style\",value:function(t,e){for(var n=this.list,r=0;r&#60;this.length;r++)n&#091;r&#093;.style&#091;t&#093;=e}}&#093;),t}(),H=\/-.\/g,Q=function(t,e){return e.toUpperCase()};function X(t){return\"function\"==typeof t?t:N}function J(t){return t?\"function\"==typeof t?t:Array.isArray(t)?function(t){var e=arguments.length&#62;1&&void 0!==arguments&#091;1&#093;?arguments&#091;1&#093;:b;if(!Array.isArray(t))return e;switch(t.length){case 1:return _(t&#091;0&#093;)||e;case 2:return _(t&#091;0&#093;,t&#091;1&#093;)||e;case 4:return w(t&#091;0&#093;,t&#091;1&#093;,t&#091;2&#093;,t&#091;3&#093;)||e}return e}(t,null):function(t,e){var n=arguments.length&#62;2&&void 0!==arguments&#091;2&#093;?arguments&#091;2&#093;:b;switch(t){case\"linear\":return b;case\"steps\":return _(e.steps||1,e.jump||0)||n;case\"bezier\":case\"cubic-bezier\":return w(e.x1||0,e.y1||0,e.x2||0,e.y2||0)||n}return n}(t.type,t.value,null):null}function K(t,e,n){var r=arguments.length&#62;3&&void 0!==arguments&#091;3&#093;&&arguments&#091;3&#093;,i=e.length-1;if(t&#60;=e&#091;0&#093;.t)return r?&#091;0,0,e&#091;0&#093;.v&#093;:e&#091;0&#093;.v;if(t&#62;=e&#091;i&#093;.t)return r?&#091;i,1,e&#091;i&#093;.v&#093;:e&#091;i&#093;.v;var o,u=e&#091;0&#093;,a=null;for(o=1;o&#60;=i;o++){if(!(t&#62;e&#091;o&#093;.t)){a=e&#091;o&#093;;break}u=e&#091;o&#093;}return null==a?r?&#091;i,1,e&#091;i&#093;.v&#093;:e&#091;i&#093;.v:u.t===a.t?r?&#091;o,1,a.v&#093;:a.v:(t=(t-u.t)\/(a.t-u.t),u.e&&(t=u.e(t)),r?&#091;o,t,n(t,u.v,a.v)&#093;:n(t,u.v,a.v))}function Z(t,e){var n=arguments.length&#62;2&&void 0!==arguments&#091;2&#093;?arguments&#091;2&#093;:null;return t&&t.length?\"function\"!=typeof e?null:(\"function\"!=typeof n&&(n=null),function(r){var i=K(r,t,e);return null!=i&&n&&(i=n(i)),i}):null}function tt(t,e){return t.t-e.t}function et(t,e,r,i,o){var u,a=\"@\"===r&#091;0&#093;,s=\"#\"===r&#091;0&#093;,l=$&#091;r&#093;,f=N;switch(a?(u=r.substr(1),r=u.replace(H,Q)):s&&(r=r.substr(1)),n(l)){case\"function\":if(f=l(i,o,K,J,r,a,e,t),s)return f;break;case\"string\":f=Z(i,X(l));break;case\"object\":if((f=Z(i,X(l.i),l.f))&&\"function\"==typeof l.u)return l.u(e,f,r,a,t)}return f?function(t,e,n){if(arguments.length&#62;3&&void 0!==arguments&#091;3&#093;&&arguments&#091;3&#093;)return t instanceof W?function(r){return t.style(e,n(r))}:function(r){return t.style&#091;e&#093;=n(r)};if(Array.isArray(e)){var r=e.length;return function(i){var o=n(i);if(null==o)for(var u=0;u&#60;r;u++)t&#091;u&#093;.removeAttribute(e);else for(var a=0;a&#60;r;a++)t&#091;a&#093;.setAttribute(e,o)}}return function(r){var i=n(r);null==i?t.removeAttribute(e):t.setAttribute(e,i)}}(e,r,f,a):null}function nt(t,e,r,i){if(!i||\"object\"!==n(i))return null;var o=null,u=null;return Array.isArray(i)?u=function(t){if(!t||!t.length)return null;for(var e=0;e&#60;t.length;e++)t&#091;e&#093;.e&&(t&#091;e&#093;.e=J(t&#091;e&#093;.e));return t.sort(tt)}(i):(u=i.keys,o=i.data||null),u?et(t,e,r,u,o):null}function rt(t,e,n){if(!n)return null;var r=&#091;&#093;;for(var i in n)if(n.hasOwnProperty(i)){var o=nt(t,e,i,n&#091;i&#093;);o&&r.push(o)}return r.length?r:null}function it(t,e){if(!e.settings.duration||e.settings.duration&#60;0)return null;var n,r,i,o,u,a=function(t,e){if(!e)return null;var n=&#091;&#093;;if(Array.isArray(e))for(var r=e.length,i=0;i&#60;r;i++){var o=e&#091;i&#093;;if(2===o.length){var u=null;if(\"string\"==typeof o&#091;0&#093;)u=t.getElementById(o&#091;0&#093;);else if(Array.isArray(o&#091;0&#093;)){u=&#091;&#093;;for(var a=0;a&#60;o&#091;0&#093;.length;a++)if(\"string\"==typeof o&#091;0&#093;&#091;a&#093;){var s=t.getElementById(o&#091;0&#093;&#091;a&#093;);s&&u.push(s)}u=u.length?1===u.length?u&#091;0&#093;:new W(u):null}if(u){var l=rt(t,u,o&#091;1&#093;);l&&(n=n.concat(l))}}}else for(var f in e)if(e.hasOwnProperty(f)){var c=t.getElementById(f);if(c){var h=rt(t,c,e&#091;f&#093;);h&&(n=n.concat(h))}}return n.length?n:null}(t,e.elements);return a?(n=a,r=e.settings,i=r.duration,o=n.length,u=null,function(t,e){var a=r.iterations||1\/0,s=(r.alternate&&a%2==0)^r.direction&#62;0?i:0,l=t%i,f=1+(t-l)\/i;e*=r.direction,r.alternate&&f%2==0&&(e=-e);var c=!1;if(f&#62;a)l=s,c=!0,-1===r.fill&&(l=r.direction&#62;0?0:i);else if(e&#60;0&&(l=i-l),l===u)return!1;u=l;for(var h=0;h&#60;o;h++)n&#091;h&#093;(l);return c}):null}function ot(t,e){if($=e,!t||!t.root||!Array.isArray(t.animations))return null;var n=function(t){for(var e=document.getElementsByTagName(\"svg\"),n=0;n&#60;e.length;n++)if(e&#091;n&#093;.id===t.root&&!e&#091;n&#093;.svgatorAnimation)return e&#091;n&#093;.svgatorAnimation=!0,e&#091;n&#093;;return null}(t);if(!n)return null;var r=t.animations.map((function(t){return it(n,t)})).filter((function(t){return!!t}));return r.length?{svg:n,animations:r,animationSettings:t.animationSettings,options:t.options||void 0}:null}function ut(t){return+(\"0x\"+(t.replace(\/&#091;^0-9a-fA-F&#093;+\/g,\"\")||27))}function at(t,e,n){return!t||!n||e&#62;t.length?t:t.substring(0,e)+at(t.substring(e+1),n,n)}function st(t){var e=arguments.length&#62;1&&void 0!==arguments&#091;1&#093;?arguments&#091;1&#093;:27;return!t||t%e?t%e:st(t\/e,e)}function lt(t,e,n){if(t&&t.length){var r=ut(n),i=ut(e),o=st(r)+5,u=at(t,st(r,5),o);return u=u.replace(\/\\x7c$\/g,\"==\").replace(\/\\x2f$\/g,\"=\"),u=function(t,e,n){var r=+(\"0x\"+t.substring(0,4));t=t.substring(4);for(var i=e%r+n%27,o=&#091;&#093;,u=0;u&#60;t.length;u+=2)if(\"|\"!==t&#091;u&#093;){var a=+(\"0x\"+t&#091;u&#093;+t&#091;u+1&#093;)-i;o.push(a)}else{var s=+(\"0x\"+t.substring(u+1,u+1+4))-i;u+=3,o.push(s)}return String.fromCharCode.apply(String,o)}(u=(u=atob(u)).replace(\/&#091;\\x41-\\x5A&#093;\/g,\"\"),i,r),u=JSON.parse(u)}}var ft=&#091;{key:\"alternate\",def:!1},{key:\"fill\",def:1},{key:\"iterations\",def:0},{key:\"direction\",def:1},{key:\"speed\",def:1},{key:\"fps\",def:100}&#093;,ct=function(){function t(e,n){var i=this,o=arguments.length&#62;2&&void 0!==arguments&#091;2&#093;?arguments&#091;2&#093;:null;r(this,t),this._id=0,this._running=!1,this._rollingBack=!1,this._animations=e,this._settings=n,(!o||o&#60;\"2022-05-02\")&&delete this._settings.speed,ft.forEach((function(t){i._settings&#091;t.key&#093;=i._settings&#091;t.key&#093;||t.def})),this.duration=n.duration,this.offset=n.offset||0,this.rollbackStartOffset=0}return o(t,&#091;{key:\"alternate\",get:function(){return this._settings.alternate}},{key:\"fill\",get:function(){return this._settings.fill}},{key:\"iterations\",get:function(){return this._settings.iterations}},{key:\"direction\",get:function(){return this._settings.direction}},{key:\"speed\",get:function(){return this._settings.speed}},{key:\"fps\",get:function(){return this._settings.fps}},{key:\"maxFiniteDuration\",get:function(){return this.iterations&#62;0?this.iterations*this.duration:this.duration}},{key:\"_apply\",value:function(t){for(var e=arguments.length&#62;1&&void 0!==arguments&#091;1&#093;?arguments&#091;1&#093;:{},n=this._animations,r=n.length,i=0,o=0;o&#60;r;o++)e&#091;o&#093;?i++:(e&#091;o&#093;=n&#091;o&#093;(t,1),e&#091;o&#093;&&i++);return i}},{key:\"_rollback\",value:function(t){var e=this,n=1\/0,r=null;this.rollbackStartOffset=t,this._rollingBack=!0,this._running=!0;this._id=window.requestAnimationFrame((function i(o){if(e._rollingBack){null==r&&(r=o);var u=Math.round(t-(o-r)*e.speed);if(u&#62;e.duration&&n!==1\/0){var a=!!e.alternate&&u\/e.duration%2&#62;1,s=u%e.duration;u=(s+=a?e.duration:0)||e.duration}var l=(e.fps?1e3\/e.fps:0)*e.speed,f=Math.max(0,u);f&#60;n-l&&(e.offset=f,n=f,e._apply(f));var c=e.iterations&#62;0&&-1===e.fill&&u&#62;=e.maxFiniteDuration;(u&#60;=0||e.offset&#60;u||c)&&e.stop(),e._id=window.requestAnimationFrame(i)}}))}},{key:\"_start\",value:function(){var t=this,e=arguments.length&#62;0&&void 0!==arguments&#091;0&#093;?arguments&#091;0&#093;:0,n=-1\/0,r=null,i={};this._running=!0;var o=function o(u){null==r&&(r=u);var a=Math.round((u-r)*t.speed+e),s=(t.fps?1e3\/t.fps:0)*t.speed;if(a&#62;n+s&&!t._rollingBack&&(t.offset=a,n=a,t._apply(a,i)===t._animations.length))return void t.pause(!0);t._id=window.requestAnimationFrame(o)};this._id=window.requestAnimationFrame(o)}},{key:\"_pause\",value:function(){this._id&&window.cancelAnimationFrame(this._id),this._running=!1}},{key:\"play\",value:function(){if(!this._running)return this._rollingBack?this._rollback(this.offset):this._start(this.offset)}},{key:\"stop\",value:function(){this._pause(),this.offset=0,this.rollbackStartOffset=0,this._rollingBack=!1,this._apply(0)}},{key:\"reachedToEnd\",value:function(){return this.iterations&#62;0&&this.offset&#62;=this.iterations*this.duration}},{key:\"restart\",value:function(){var t=arguments.length&#62;0&&void 0!==arguments&#091;0&#093;&&arguments&#091;0&#093;;this.stop(t),this.play(t)}},{key:\"pause\",value:function(){this._pause()}},{key:\"reverse\",value:function(){this.direction=-this.direction}}&#093;,&#091;{key:\"build\",value:function(t,e){delete t.animationSettings,t.options=lt(t.options,t.root,\"91c80d77\"),t.animations.map((function(e){e.settings=lt(e.s,t.root,\"91c80d77\"),delete e.s,t.animationSettings||(t.animationSettings=e.settings)}));var n=t.version;if(!(t=ot(t,e)))return null;var r=t.options||{},i=new this(t.animations,t.animationSettings,n);return{el:t.svg,options:r,player:i}}},{key:\"push\",value:function(t){return this.build(t)}},{key:\"init\",value:function(){var t=this,e=window.__SVGATOR_PLAYER__&&window.__SVGATOR_PLAYER__&#091;\"91c80d77\"&#093;;Array.isArray(e)&&e.splice(0).forEach((function(e){return t.build(e)}))}}&#093;),t}();!function(){for(var t=0,e=&#091;\"ms\",\"moz\",\"webkit\",\"o\"&#093;,n=0;n&#60;e.length&&!window.requestAnimationFrame;++n)window.requestAnimationFrame=window&#091;e&#091;n&#093;+\"RequestAnimationFrame\"&#093;,window.cancelAnimationFrame=window&#091;e&#091;n&#093;+\"CancelAnimationFrame\"&#093;||window&#091;e&#091;n&#093;+\"CancelRequestAnimationFrame\"&#093;;window.requestAnimationFrame||(window.requestAnimationFrame=function(e){var n=Date.now(),r=Math.max(0,16-(n-t)),i=window.setTimeout((function(){e(n+r)}),r);return t=n+r,i},window.cancelAnimationFrame=window.clearTimeout)}();var ht=function(t,e){var n=!1,r=null;return function(i){n&&clearTimeout(n),n=setTimeout((function(){return function(){for(var i=0,o=window.innerHeight,u=0,a=window.innerWidth,s=t.parentNode;s instanceof Element;){var l=window.getComputedStyle(s);if(\"visible\"!==l.overflowY||\"visible\"!==l.overflowX){var f=s.getBoundingClientRect();\"visible\"!==l.overflowY&&(i=Math.max(i,f.top),o=Math.min(o,f.bottom)),\"visible\"!==l.overflowX&&(u=Math.max(u,f.left),a=Math.min(a,f.right))}if(s===s.parentNode)break;s=s.parentNode}n=!1;var c=t.getBoundingClientRect(),h=Math.min(c.height,Math.max(0,i-c.top)),v=Math.min(c.height,Math.max(0,c.bottom-o)),y=Math.min(c.width,Math.max(0,u-c.left)),d=Math.min(c.width,Math.max(0,c.right-a)),g=(c.height-h-v)\/c.height,p=(c.width-y-d)\/c.width,m=Math.round(g*p*100);null!==r&&r===m||(r=m,e(m))}()}),100)}},vt=function(){function t(e,n,i){r(this,t),n=Math.max(1,n||1),n=Math.min(n,100),this.el=e,this._handlers=&#091;&#093;,this.onThresholdChange=i&&i.call?i:function(){},this.thresholdPercent=n||1,this.currentVisibility=null,this.visibilityCalculator=ht(e,this.onVisibilityUpdate.bind(this)),this.bindScrollWatchers(),this.visibilityCalculator()}return o(t,&#091;{key:\"bindScrollWatchers\",value:function(){for(var t=this.el.parentNode;t&&(this._handlers.push({element:t,event:\"scroll\",handler:this.visibilityCalculator}),t.addEventListener(\"scroll\",this.visibilityCalculator),t!==t.parentNode&&t!==document);)t=t.parentNode}},{key:\"onVisibilityUpdate\",value:function(t){var e=this.currentVisibility&#62;=this.thresholdPercent,n=t&#62;=this.thresholdPercent;if(null===this.currentVisibility||e!==n)return this.currentVisibility=t,void this.onThresholdChange(n);this.currentVisibility=t}},{key:\"destruct\",value:function(){this._handlers.forEach((function(t){t.element.removeEventListener(t.event,t.handler)}))}}&#093;),t}();function yt(t){return g(t)+\"\"}function dt(t){var e=arguments.length&#62;1&&void 0!==arguments&#091;1&#093;?arguments&#091;1&#093;:\" \";return t&&t.length?t.map(yt).join(e):\"\"}function gt(t){return yt(t.x)+\",\"+yt(t.y)}function pt(t){if(!t)return\"transparent\";if(null==t.a||t.a&#62;=1){var e=function(t){return 1===(t=parseInt(t).toString(16)).length?\"0\"+t:t},n=function(t){return t.charAt(0)===t.charAt(1)},r=e(t.r),i=e(t.g),o=e(t.b);return n(r)&&n(i)&&n(o)&&(r=r.charAt(0),i=i.charAt(0),o=o.charAt(0)),\"#\"+r+i+o}return\"rgba(\"+t.r+\",\"+t.g+\",\"+t.b+\",\"+t.a+\")\"}function mt(t){return t?\"url(#\"+t+\")\":\"none\"}var bt={f:null,i:q,u:function(t,e){return function(n){var r=e(n);t.setAttribute(\"rx\",yt(r.x)),t.setAttribute(\"ry\",yt(r.y))}}},kt={f:null,i:function(t,e,n){return 0===t?e:1===t?n:{width:C(t,e.width,n.width),height:C(t,e.height,n.height)}},u:function(t,e){return function(n){var r=e(n);t.setAttribute(\"width\",yt(r.width)),t.setAttribute(\"height\",yt(r.height))}}};Object.freeze({M:2,L:2,Z:0,H:1,V:1,C:6,Q:4,T:2,S:4,A:7});var wt={},xt=null;function At(t){var e=function(){if(xt)return xt;if(\"object\"!==(\"undefined\"==typeof document?\"undefined\":n(document))||!document.createElementNS)return{};var t=document.createElementNS(\"http:\/\/www.w3.org\/2000\/svg\",\"svg\");return t&&t.style?(t.style.position=\"absolute\",t.style.opacity=\"0.01\",t.style.zIndex=\"-9999\",t.style.left=\"-9999px\",t.style.width=\"1px\",t.style.height=\"1px\",xt={svg:t}):{}}().svg;if(!e)return function(t){return null};var r=document.createElementNS(e.namespaceURI,\"path\");r.setAttributeNS(null,\"d\",t),r.setAttributeNS(null,\"fill\",\"none\"),r.setAttributeNS(null,\"stroke\",\"none\"),e.appendChild(r);var i=r.getTotalLength();return function(t){var e=r.getPointAtLength(i*t);return{x:e.x,y:e.y}}}function _t(t){return wt&#091;t&#093;?wt&#091;t&#093;:wt&#091;t&#093;=At(t)}function Ot(t,e,n,r){if(!t||!r)return!1;var i=&#091;\"M\",t.x,t.y&#093;;if(e&&n&&(i.push(\"C\"),i.push(e.x),i.push(e.y),i.push(n.x),i.push(n.y)),e?!n:n){var o=e||n;i.push(\"Q\"),i.push(o.x),i.push(o.y)}return e||n||i.push(\"L\"),i.push(r.x),i.push(r.y),i.join(\" \")}function St(t,e,n,r){var i=arguments.length&#62;4&&void 0!==arguments&#091;4&#093;?arguments&#091;4&#093;:1,o=Ot(t,e,n,r),u=_t(o);try{return u(i)}catch(t){return null}}function Et(t,e,n){return t+(e-t)*n}function Pt(t,e,n){var r=arguments.length&#62;3&&void 0!==arguments&#091;3&#093;&&arguments&#091;3&#093;,i={x:Et(t.x,e.x,n),y:Et(t.y,e.y,n)};return r&&(i.a=Mt(t,e)),i}function Mt(t,e){return Math.atan2(e.y-t.y,e.x-t.x)}function jt(t,e,n,r){var i=1-r;return i*i*t+2*i*r*e+r*r*n}function Bt(t,e,n,r){return 2*(1-r)*(e-t)+2*r*(n-e)}function Tt(t,e,n,r){var i=arguments.length&#62;4&&void 0!==arguments&#091;4&#093;&&arguments&#091;4&#093;,o=St(t,e,null,n,r);return o||(o={x:jt(t.x,e.x,n.x,r),y:jt(t.y,e.y,n.y,r)}),i&&(o.a=It(t,e,n,r)),o}function It(t,e,n,r){return Math.atan2(Bt(t.y,e.y,n.y,r),Bt(t.x,e.x,n.x,r))}function Rt(t,e,n,r,i){var o=i*i;return i*o*(r-t+3*(e-n))+3*o*(t+n-2*e)+3*i*(e-t)+t}function Nt(t,e,n,r,i){var o=1-i;return 3*(o*o*(e-t)+2*o*i*(n-e)+i*i*(r-n))}function Ft(t,e,n,r,i){var o=arguments.length&#62;5&&void 0!==arguments&#091;5&#093;&&arguments&#091;5&#093;,u=St(t,e,n,r,i);return u||(u={x:Rt(t.x,e.x,n.x,r.x,i),y:Rt(t.y,e.y,n.y,r.y,i)}),o&&(u.a=Ct(t,e,n,r,i)),u}function Ct(t,e,n,r,i){return Math.atan2(Nt(t.y,e.y,n.y,r.y,i),Nt(t.x,e.x,n.x,r.x,i))}function Lt(t,e,n){var r=arguments.length&#62;3&&void 0!==arguments&#091;3&#093;&&arguments&#091;3&#093;;if(qt(e)){if(Vt(n))return Tt(e,n.start,n,t,r)}else if(qt(n)){if(zt(e))return Tt(e,e.end,n,t,r)}else{if(zt(e))return Vt(n)?Ft(e,e.end,n.start,n,t,r):Tt(e,e.end,n,t,r);if(Vt(n))return Tt(e,n.start,n,t,r)}return Pt(e,n,t,r)}function Dt(t,e,n){var r=Lt(t,e,n,!0);return r.a=function(t){return arguments.length&#62;1&&void 0!==arguments&#091;1&#093;&&arguments&#091;1&#093;?t+Math.PI:t}(r.a)\/m,r}function qt(t){return!t.type||\"corner\"===t.type}function Vt(t){return null!=t.start&&!qt(t)}function zt(t){return null!=t.end&&!qt(t)}var Yt=new R;var Gt={f:function(t){return t?t.join(\" \"):\"\"},i:function(t,e,r){if(0===t)return e;if(1===t)return r;var i=e.length;if(i!==r.length)return N(t,e,r);for(var o,u=new Array(i),a=0;a&#60;i;a++){if((o=n(e&#091;a&#093;))!==n(r&#091;a&#093;))return N(t,e,r);if(\"number\"===o)u&#091;a&#093;=F(t,e&#091;a&#093;,r&#091;a&#093;);else{if(e&#091;a&#093;!==r&#091;a&#093;)return N(t,e,r);u&#091;a&#093;=e&#091;a&#093;}}return u}},Ut={f:null,i:Y,u:function(t,e){return function(n){var r=e(n);t.setAttribute(\"x1\",yt(r&#091;0&#093;)),t.setAttribute(\"y1\",yt(r&#091;1&#093;)),t.setAttribute(\"x2\",yt(r&#091;2&#093;)),t.setAttribute(\"y2\",yt(r&#091;3&#093;))}}},$t={f:yt,i:F},Wt={f:yt,i:L},Ht={f:function(t){var e=arguments.length&#62;1&&void 0!==arguments&#091;1&#093;?arguments&#091;1&#093;:\" \";return t&&t.length&#62;0&&(t=t.map((function(t){return g(t,4)}))),dt(t,e)},i:function(t,e,n){var r,i,o,u=e.length,a=n.length;if(u!==a)if(0===u)e=G(u=a,0);else if(0===a)a=u,n=G(u,0);else{var s=(o=(r=u)*(i=a)\/function(t,e){for(var n;e;)n=e,e=t%e,t=n;return t||1}(r,i))&#60;0?-o:o;e=U(e,Math.floor(s\/u)),n=U(n,Math.floor(s\/a)),u=a=s}for(var l=&#091;&#093;,f=0;f&#60;u;f++)l.push(g(C(t,e&#091;f&#093;,n&#091;f&#093;)));return l}};function Qt(t,e,n){return t.map((function(t){return function(t,e,n){var r=t.v;if(!r||\"g\"!==r.t||r.s||!r.v||!r.r)return t;var i=n.getElementById(r.r),o=i&&i.querySelectorAll(\"stop\")||&#091;&#093;;return r.s=r.v.map((function(t,e){var n=o&#091;e&#093;&&o&#091;e&#093;.getAttribute(\"offset\");return{c:t,o:n=g(parseInt(n)\/100)}})),delete r.v,t}(t,0,n)}))}var Xt={gt:\"gradientTransform\",c:{x:\"cx\",y:\"cy\"},rd:\"r\",f:{x:\"x1\",y:\"y1\"},to:{x:\"x2\",y:\"y2\"}};function Jt(t,e,r,i,o,u,a,s){return Qt(t,0,s),e=function(t,e,n){for(var r,i,o,u=t.length-1,a={},s=0;s&#60;=u;s++)(r=t&#091;s&#093;).e&&(r.e=e(r.e)),r.v&&\"g\"===(i=r.v).t&&i.r&&(o=n.getElementById(i.r))&&(a&#091;i.r&#093;={e:o,s:o.querySelectorAll(\"stop\")});return a}(t,i,s),function(i){var o=r(i,t,Kt);if(!o)return\"none\";if(\"c\"===o.t)return pt(o.v);if(\"g\"===o.t){if(!e&#091;o.r&#093;)return mt(o.r);var u=e&#091;o.r&#093;;return function(t,e){for(var n=t.s,r=n.length;r&#60;e.length;r++){var i=n&#091;n.length-1&#093;.cloneNode();i.id=ee(i.id),t.e.appendChild(i),n=t.s=t.e.querySelectorAll(\"stop\")}for(var o=0,u=n.length,a=e.length-1;o&#60;u;o++)n&#091;o&#093;.setAttribute(\"stop-color\",pt(e&#091;Math.min(o,a)&#093;.c)),n&#091;o&#093;.setAttribute(\"offset\",e&#091;Math.min(o,a)&#093;.o)}(u,o.s),Object.keys(Xt).forEach((function(t){if(void 0!==o&#091;t&#093;)if(\"object\"!==n(Xt&#091;t&#093;)){var e,r=\"gt\"===t?(e=o&#091;t&#093;,Array.isArray(e)?\"matrix(\"+e.join(\" \")+\")\":\"\"):o&#091;t&#093;,i=Xt&#091;t&#093;;u.e.setAttribute(i,r)}else Object.keys(Xt&#091;t&#093;).forEach((function(e){if(void 0!==o&#091;t&#093;&#091;e&#093;){var n=o&#091;t&#093;&#091;e&#093;,r=Xt&#091;t&#093;&#091;e&#093;;u.e.setAttribute(r,n)}}))})),mt(o.r)}return\"none\"}}function Kt(t,n,r){if(0===t)return n;if(1===t)return r;if(n&&r){var i=n.t;if(i===r.t)switch(n.t){case\"c\":return{t:i,v:z(t,n.v,r.v)};case\"g\":if(n.r===r.r){var o={t:i,s:Zt(t,n.s,r.s),r:n.r};return n.gt&&r.gt&&(o.gt=Y(t,n.gt,r.gt)),n.c?(o.c=D(t,n.c,r.c),o.rd=C(t,n.rd,r.rd)):n.f&&(o.f=D(t,n.f,r.f),o.to=D(t,n.to,r.to)),o}}if(\"c\"===n.t&&\"g\"===r.t||\"c\"===r.t&&\"g\"===n.t){var u=\"c\"===n.t?n:r,a=\"g\"===n.t?e({},n):e({},r),s=a.s.map((function(t){return{c:u.v,o:t.o}}));return a.s=\"c\"===n.t?Zt(t,s,a.s):Zt(t,a.s,s),a}}return N(t,n,r)}function Zt(t,e,n){if(e.length===n.length)return e.map((function(e,r){return te(t,e,n&#091;r&#093;)}));for(var r=Math.max(e.length,n.length),i=&#091;&#093;,o=0;o&#60;r;o++){var u=te(t,e&#091;Math.min(o,e.length-1)&#093;,n&#091;Math.min(o,n.length-1)&#093;);i.push(u)}return i}function te(t,e,n){return{o:L(t,e.o,n.o||0),c:z(t,e.c,n.c||{})}}function ee(t){return t.replace(\/-fill-(&#091;0-9&#093;+)$\/,(function(t,e){return\"-fill-\"+(+e+1)}))}var ne={blur:q,brightness:C,contrast:C,\"drop-shadow\":function(t,e,n){return 0===t?e:1===t?n:{blur:q(t,e.blur,n.blur),offset:D(t,e.offset,n.offset),color:z(t,e.color,n.color)}},grayscale:C,\"hue-rotate\":F,invert:C,opacity:C,saturate:C,sepia:C};function re(t,e,n){if(0===t)return e;if(1===t)return n;var r=e.length;if(r!==n.length)return N(t,e,n);for(var i,o=&#091;&#093;,u=0;u&#60;r;u++){if(e&#091;u&#093;.type!==n&#091;u&#093;.type)return e;if(!(i=ne&#091;e&#091;u&#093;.type&#093;))return N(t,e,n);o.push({type:e.type,value:i(t,e&#091;u&#093;.value,n&#091;u&#093;.value)})}return o}var ie={blur:function(t){return t?function(e){t.setAttribute(\"stdDeviation\",gt(e))}:null},brightness:function(t,e,n){return(t=ue(n,e))?function(e){e=yt(e),t.map((function(t){return t.setAttribute(\"slope\",e)}))}:null},contrast:function(t,e,n){return(t=ue(n,e))?function(e){var n=yt((1-e)\/2);e=yt(e),t.map((function(t){t.setAttribute(\"slope\",e),t.setAttribute(\"intercept\",n)}))}:null},\"drop-shadow\":function(t,e,n){var r=n.getElementById(e+\"-blur\");if(!r)return null;var i=n.getElementById(e+\"-offset\");if(!i)return null;var o=n.getElementById(e+\"-flood\");return o?function(t){r.setAttribute(\"stdDeviation\",gt(t.blur)),i.setAttribute(\"dx\",yt(t.offset.x)),i.setAttribute(\"dy\",yt(t.offset.y)),o.setAttribute(\"flood-color\",pt(t.color))}:null},grayscale:function(t){return t?function(e){t.setAttribute(\"values\",dt(function(t){return&#091;.2126+.7874*(t=1-t),.7152-.7152*t,.0722-.0722*t,0,0,.2126-.2126*t,.7152+.2848*t,.0722-.0722*t,0,0,.2126-.2126*t,.7152-.7152*t,.0722+.9278*t,0,0,0,0,0,1,0&#093;}(e)))}:null},\"hue-rotate\":function(t){return t?function(e){return t.setAttribute(\"values\",yt(e))}:null},invert:function(t,e,n){return(t=ue(n,e))?function(e){e=yt(e)+\" \"+yt(1-e),t.map((function(t){return t.setAttribute(\"tableValues\",e)}))}:null},opacity:function(t,e,n){return(t=n.getElementById(e+\"-A\"))?function(e){return t.setAttribute(\"tableValues\",\"0 \"+yt(e))}:null},saturate:function(t){return t?function(e){return t.setAttribute(\"values\",yt(e))}:null},sepia:function(t){return t?function(e){return t.setAttribute(\"values\",dt(function(t){return&#091;.393+.607*(t=1-t),.769-.769*t,.189-.189*t,0,0,.349-.349*t,.686+.314*t,.168-.168*t,0,0,.272-.272*t,.534-.534*t,.131+.869*t,0,0,0,0,0,1,0&#093;}(e)))}:null}};var oe=&#091;\"R\",\"G\",\"B\"&#093;;function ue(t,e){var n=oe.map((function(n){return t.getElementById(e+\"-\"+n)||null}));return-1!==n.indexOf(null)?null:n}var ae={fill:Jt,\"fill-opacity\":Wt,stroke:Jt,\"stroke-opacity\":Wt,\"stroke-width\":$t,\"stroke-dashoffset\":{f:yt,i:F},\"stroke-dasharray\":Ht,opacity:Wt,transform:function(t,e,r,i){if(!(t=function(t,e){if(!t||\"object\"!==n(t))return null;var r=!1;for(var i in t)t.hasOwnProperty(i)&&(t&#091;i&#093;&&t&#091;i&#093;.length?(t&#091;i&#093;.forEach((function(t){t.e&&(t.e=e(t.e))})),r=!0):delete t&#091;i&#093;);return r?t:null}(t,i)))return null;var o=function(n,i,o){var u=arguments.length&#62;3&&void 0!==arguments&#091;3&#093;?arguments&#091;3&#093;:null;return t&#091;n&#093;?r(i,t&#091;n&#093;,o):e&&e&#091;n&#093;?e&#091;n&#093;:u};return e&&e.a&&t.o?function(e){var n=r(e,t.o,Dt);return Yt.recomposeSelf(n,o(\"r\",e,F,0)+n.a,o(\"k\",e,D),o(\"s\",e,D),o(\"t\",e,D)).toString()}:function(t){return Yt.recomposeSelf(o(\"o\",t,Lt,null),o(\"r\",t,F,0),o(\"k\",t,D),o(\"s\",t,D),o(\"t\",t,D)).toString()}},\"#filter\":function(t,e,n,r,i,o,u,a){if(!e.items||!t||!t.length)return null;var s=function(t,e){var n=(t=t.map((function(t){return t&&ie&#091;t&#091;0&#093;&#093;?(e.getElementById(t&#091;1&#093;),ie&#091;t&#091;0&#093;&#093;(e.getElementById(t&#091;1&#093;),t&#091;1&#093;,e)):null}))).length;return function(e){for(var r=0;r&#60;n;r++)t&#091;r&#093;&&t&#091;r&#093;(e&#091;r&#093;.value)}}(e.items,a);return s?(t=function(t,e){return t.map((function(t){return t.e=e(t.e),t}))}(t,r),function(e){s(n(e,t,re))}):null},\"#line\":Ut,points:{f:dt,i:Y},d:Gt,r:$t,\"#size\":kt,\"#radius\":bt,_:function(t,e){if(Array.isArray(t))for(var n=0;n&#60;t.length;n++)this&#091;t&#091;n&#093;&#093;=e;else this&#091;t&#093;=e}},se={currentTime:\"offset\",duration:\"duration\",hasEnded:function(){return this.reachedToEnd()},isAlternate:\"alternate\",isPlaying:\"_running\",isRollingBack:\"_rollingBack\",state:function(t,e){return e.isPlaying?e.isRollingBack?\"rollback\":\"playing\":e.hasEnded?\"ended\":\"paused\"},totalTime:\"maxFiniteDuration\",iterations:\"iterations\",direction:\"direction\",fill:\"fill\",isReversed:function(t,e){return-1===e.direction},isBackwards:function(t,e){return-1===e.fill},isInfinite:function(t,e){return 0===e.iterations},speed:\"speed\",fps:\"fps\"},le={destruct:\"destruct\",pause:\"pause\",play:function(t,e){return fe(t,e.hasEnded?\"restart\":\"play\",e)},restart:\"restart\",reverse:function(t,e){return fe(t,\"reverse\",e,&#091;!0&#093;)},seek:\"seek\",seekBy:\"seekBy\",seekTo:\"seekTo\",stop:\"stop\",toggle:\"toggle\",togglePlay:\"toggle\",set:\"set\"};function fe(t,e,n){var r=arguments.length&#62;3&&void 0!==arguments&#091;3&#093;?arguments&#091;3&#093;:&#091;&#093;;return function(){var i,o=Array.prototype.slice.call(arguments);return o.unshift.apply(o,v(r)),(i=t&#091;e&#093;).call.apply(i,&#091;t&#093;.concat(v(o))),n}}var ce=function t(e){r(this,t);var n={},i=&#091;\"on\",\"off\"&#093;,o={get:function(t,e,r){return se&#091;e&#093;?\"function\"==typeof se&#091;e&#093;?se&#091;e&#093;.call(t,t,r):t&#091;se&#091;e&#093;&#093;:le&#091;e&#093;?\"function\"==typeof le&#091;e&#093;?le&#091;e&#093;.call(t,t,r):fe(t,le&#091;e&#093;,r):-1!==i.indexOf(e)?n&#091;e&#093;:\"ready\"===e?function(t){return t&&t.call(r,r),r}:void 0},set:function(t,e,r){return-1!==i.indexOf(e)&&(n&#091;e&#093;=r)},ownKeys:function(t){return Object.keys(se)},has:function(t,e){return void 0!==se&#091;e&#093;}};if(\"function\"==typeof Proxy)return new Proxy(e,o);var u=Object.keys(se).concat(Object.keys(le)).concat(i),a={};return u.forEach((function(t){var n={enumerable:!1,configurable:!1,get:function(){return o.get(e,t,a)}};-1!==i.indexOf(t)&&(n.set=function(n){return o.set(e,t,n)}),Object.defineProperty(a,t,n)})),a};function he(t){t||(t=this);var e={};this.on=function(t,n){var r=arguments.length&#62;2&&void 0!==arguments&#091;2&#093;&&arguments&#091;2&#093;;return\"function\"==typeof n&&(t.split(\/&#091;, &#093;+\/g).forEach((function(t){return e&#091;t&#093;=e&#091;t&#093;||&#091;&#093;,r?e&#091;t&#093;.unshift(n):e&#091;t&#093;.push(n)})),!0)},this.off=function(t,n){for(var r in e)if(e.hasOwnProperty(r)&&r.substr(0,t.length)===t)if(n)for(var i=0;i&#60;e&#091;r&#093;.length;i++)e&#091;r&#093;&#091;i&#093;===n&&(e&#091;r&#093;&#091;i&#093;=null);else e&#091;r&#093;=null},this.trigger=function(){var n,r=Array.prototype.slice.call(arguments),i=r&#091;0&#093;,o=r.slice(1);t:for(var u in e)if(e.hasOwnProperty(u)&&e&#091;u&#093;&&(u===i||u.substr(0,i.length+1)===i+\".\"))for(var a=0;a&#60;e&#091;u&#093;.length;a++)if(e&#091;u&#093;&#091;a&#093;&&!1===(n=e&#091;u&#093;&#091;a&#093;.apply(t,o)))break t;return n}}var ve=!0,ye=&#091;\"iterations\",\"speed\",\"fps\",\"direction\",\"fill\",\"alternate\"&#093;,de=function(t){!function(t,e){if(\"function\"!=typeof e&&null!==e)throw new TypeError(\"Super expression must either be null or a function\");t.prototype=Object.create(e&&e.prototype,{constructor:{value:t,writable:!0,configurable:!0}}),e&&s(t,e)}(u,t);var e,n,i=(e=u,n=l(),function(){var t,r=a(e);if(n){var i=a(this).constructor;t=Reflect.construct(r,arguments,i)}else t=r.apply(this,arguments);return c(this,t)});function u(t,e){var n,o=arguments.length&#62;2&&void 0!==arguments&#091;2&#093;?arguments&#091;2&#093;:null;return r(this,u),(n=i.call(this,t,e,o))._handlers=&#091;&#093;,n}return o(u,&#091;{key:\"_adjustOffset\",value:function(){var t=arguments.length&#62;0&&void 0!==arguments&#091;0&#093;&&arguments&#091;0&#093;,e=this.alternate?2*this.duration:this.duration;if(t){if(!this._rollingBack&&0===this.offset)return void(this.offset=e);this._rollingBack&&(this.offset,this.maxFiniteDuration)}!this._rollingBack||this.rollbackStartOffset&#60;=this.duration?0!==this.iterations&&(this.offset=Math.min(this.offset,this.maxFiniteDuration)):(this.offset=this.rollbackStartOffset-(this.rollbackStartOffset-this.offset)%e,this.rollbackStartOffset=0)}},{key:\"reverse\",value:function(){var t=arguments.length&#62;0&&void 0!==arguments&#091;0&#093;&&arguments&#091;0&#093;;if(!this._running)return this._adjustOffset(t),this._rollingBack=!this._rollingBack,t&&this.play(!1),void this.trigger(\"reverse\",this.offset);this.pause(!1,!1),this._adjustOffset(),this._rollingBack=!this._rollingBack,this.play(!1),this.trigger(\"reverse\",this.offset)}},{key:\"play\",value:function(){var t=arguments.length&#62;0&&void 0!==arguments&#091;0&#093;?arguments&#091;0&#093;:ve,e=h(a(u.prototype),\"play\",this).call(this);return t===ve&&this.trigger(\"play\",this.offset),e}},{key:\"pause\",value:function(){var t=arguments.length&#62;0&&void 0!==arguments&#091;0&#093;&&arguments&#091;0&#093;,e=arguments.length&#62;1&&void 0!==arguments&#091;1&#093;?arguments&#091;1&#093;:ve,n=h(a(u.prototype),\"pause\",this).call(this);return e===ve&&this.trigger(t?\"end\":\"pause\",this.offset),n}},{key:\"restart\",value:function(){var t=h(a(u.prototype),\"restart\",this).call(this,!1);return this.trigger(\"restart\",this.offset),t}},{key:\"stop\",value:function(){var t=arguments.length&#62;0&&void 0!==arguments&#091;0&#093;?arguments&#091;0&#093;:ve,e=h(a(u.prototype),\"stop\",this).call(this);return t===ve&&this.trigger(\"stop\",this.offset),e}},{key:\"_apply\",value:function(t){var e=this,n=arguments.length&#62;2&&void 0!==arguments&#091;2&#093;?arguments&#091;2&#093;:ve,r=h(a(u.prototype),\"_apply\",this).call(this,t);if(n===ve){var i=function(){return e.trigger(\"keyframe\",t)};window.requestAnimationFrame(i)}return r}},{key:\"seekTo\",value:function(t){var e,n,r,i=this._running;i&&this.pause(!1,!1),this.offset=this.iterations&#62;0?(e=t,n=0,r=this.maxFiniteDuration,e&#60;n?n:e&#62;r?r:e):Math.max(t,0),this._apply(this.offset),i&&this.play(!1)}},{key:\"seek\",value:function(t){return this.seekTo(Math.round(t\/100*this.maxFiniteDuration))}},{key:\"seekBy\",value:function(t){return this.seekTo(this.offset+t)}},{key:\"toggle\",value:function(){return this._running?this.pause():this.reachedToEnd()?this.restart():this.play()}},{key:\"set\",value:function(t,e){if(ye.includes(t)){var n=this._running;n&&this.pause(!1,!1),this._settings&#091;t&#093;=e,n?this.play(!1):this._apply(this.offset,{},!1)}}},{key:\"destruct\",value:function(){var t=this;this.stop(),this._handlers.forEach((function(t){t.element?t.element.removeEventListener(t.event,t.handler):t.callback&&t.callback.call&&t.callback.call()}));var e=function(){},n=Object.getOwnPropertyNames(Object.getPrototypeOf(this));n.push.apply(n,v(Object.getOwnPropertyNames(this))),n.forEach((function(n){\"function\"==typeof t&#091;n&#093;?t&#091;n&#093;=e:delete t&#091;n&#093;}))}}&#093;,&#091;{key:\"build\",value:function(t){var e=h(a(u),\"build\",this).call(this,t,ae);if(!e)return null;var n=e.el,r=e.options,i=e.player,o=new ce(i),s=new he(o);o.on=s.on,o.off=s.off,i.trigger=s.trigger;var l=n.svgatorPlayer&&n.svgatorPlayer.ready&&n.svgatorPlayer.ready.call&&n.svgatorPlayer.ready.call();n.svgatorPlayer=o,function(t,e,n){if(\"click\"===n.start){var r=function(){switch(n.click){case\"freeze\":return!t._running&&t.reachedToEnd()?t.restart():t.toggle();case\"restart\":return t.offset&#62;0?t.restart():t.play();case\"reverse\":return t._running?t.reverse():t.reachedToEnd()?1===t.fill?t.reverse(!0):t.restart():t.play();case\"none\":default:if(t._running)return;return t.reachedToEnd()?t.restart():t.play()}};return t._handlers.push({element:e,event:\"click\",handler:r}),void e.addEventListener(\"click\",r)}if(\"hover\"===n.start){var i=function(){return t.reachedToEnd()?t.restart():t._rollingBack?t.reverse():t.play()};t._handlers.push({element:e,event:\"mouseenter\",handler:i}),e.addEventListener(\"mouseenter\",i);var o=function(){switch(n.hover){case\"freeze\":return t.pause();case\"reset\":return t.stop();case\"reverse\":if(t.reverse(),t._running)return;return t.play();case\"none\":default:return}};return t._handlers.push({element:e,event:\"mouseleave\",handler:o}),void e.addEventListener(\"mouseleave\",o)}if(\"scroll\"===n.start){var u=new vt(e,n.scroll||25,(function(e){e?t.reachedToEnd()?t.restart():t.play():t.pause()}));return void t._handlers.push({callback:function(){return u.destruct()}})}if(\"programmatic\"===n.start)return;t.play()}(i,n,r),function(t,e,n){var r;\"function\"==typeof Event?r=new Event(\"ready\"):(r=document.createEvent(\"Event\")).initEvent(\"ready\",!0,!0);if(t.dispatchEvent(r),!n||!n.length)return;n.forEach((function(t){return e.ready(t)}))}(n,n.svgatorPlayer,l)}}&#093;),u}(ct);return de.init(),de}));\n(function(s,i,o,w,a,b){(a=document.getElementById(i.root)).svgatorPlayer={ready:(function(a){b=&#091;&#093;;return function(c){return c?(b.push(c),a.svgatorPlayer):b}})(a)};w&#091;o&#093;=w&#091;o&#093;||{};w&#091;o&#093;&#091;s&#093;=w&#091;o&#093;&#091;s&#093;||&#091;&#093;;w&#091;o&#093;&#091;s&#093;.push(i);})('91c80d77',{\"root\":\"eMPFgTbyUiR1\",\"version\":\"2022-05-04\",\"animations\":&#091;{\"elements\":{\"eMPFgTbyUiR28\":{\"stroke-dashoffset\":&#091;{\"t\":0,\"v\":352.27},{\"t\":500,\"v\":0}&#093;},\"eMPFgTbyUiR29\":{\"stroke-dashoffset\":&#091;{\"t\":0,\"v\":188.5},{\"t\":500,\"v\":188.5},{\"t\":1000,\"v\":0},{\"t\":1500,\"v\":0}&#093;,\"stroke-dasharray\":&#091;{\"t\":0,\"v\":&#091;188.5&#093;},{\"t\":500,\"v\":&#091;188.5&#093;},{\"t\":1000,\"v\":&#091;0&#093;},{\"t\":1500,\"v\":&#091;2,12&#093;}&#093;},\"eMPFgTbyUiR30\":{\"stroke-dashoffset\":&#091;{\"t\":0,\"v\":771.802051},{\"t\":1500,\"v\":771.802051},{\"t\":2500,\"v\":0},{\"t\":3500,\"v\":0}&#093;,\"stroke-dasharray\":&#091;{\"t\":0,\"v\":&#091;771.802051&#093;},{\"t\":1500,\"v\":&#091;771.802051&#093;},{\"t\":2500,\"v\":&#091;0&#093;},{\"t\":3500,\"v\":&#091;2,12&#093;}&#093;},\"eMPFgTbyUiR31\":{\"stroke-dashoffset\":&#091;{\"t\":0,\"v\":410.64},{\"t\":3500,\"v\":410.64},{\"t\":4000,\"v\":0}&#093;}},\"s\":\"MDWA1Mzk5NDA4MEjkzOTA3Zlk5PMjg3OGQ4YzQQwNTg1MjRlNGPU0ZTRhNDA4MOjg3OTA4MzgxVOTI4N0w4ZDhAjNDA1ODRmNGSE0MDg3OTI4MBzkwN2Y5Mjg3XOGQ4YzkxNDAU1ODRmNGFFNDSA4NDg3OGE4YCTQwNTg0ZjRhUVTQwN2Y4YTkJyODM5MDhjSDNdmOTI4MzQwNRThBODQ3ZjhhUOTE4MzRhNDAU5MThlT1I4MzCgzODI0MEY1OEE40Zjli\"}&#093;,\"options\":\"MDKAxZThjMzM4NEDg1QTcyODM4ANTMzNGIzMzgN0NzQ4MzgwRDPdkN2RCMzMzZXDMzWTg0NzQ4KMzgwN2Q3ZDMQzNGI0MjQxOGVU\/\"},'__SVGATOR_PLAYER__',window)<\/script><\/svg>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0e25d05 ct-callout elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"0e25d05\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Visite <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03566043\" target=\"_blank\" rel=\"noopener\">ClinicalTrials.gov<\/a> utilizando el identificador NCT03566043 para obtener m\u00e1s informaci\u00f3n sobre este estudio, incluidos los criterios de elegibilidad.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f411321 find-a-study elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"f411321\" data-element_type=\"section\" data-e-type=\"section\" id=\"campsiite-locations\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-306c346 card\" data-id=\"306c346\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b447801 elementor-widget elementor-widget-text-editor\" data-id=\"b447801\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>Encuentre la ubicaci\u00f3n del centro del estudio cerca de usted.<\/h3>\n<p>Se espera que el estudio CAMPSIITE\u2122 incluya centros en Estados Unidos, Brasil y Canad\u00e1.<\/p>\n<p><a class=\"button\" href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03566043\">Visite ClinicalTrials.gov (identificador n.\u00ba NCT03566043) para obtener una lista completa de los centros del ensayo.<\/a><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d80affa elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d80affa\" data-element_type=\"section\" data-e-type=\"section\" id=\"contact-us\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ee80b9c\" data-id=\"ee80b9c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e3b09e7 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e3b09e7\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>P\u00f3ngase en contacto con nosotros<\/h2>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7848df7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7848df7\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-6a79c26 narrow-col elementor-invisible\" data-id=\"6a79c26\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f22079c elementor-widget elementor-widget-text-editor\" data-id=\"f22079c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Si desea ponerse en contacto con un miembro de nuestro equipo de apoyo al paciente, puede enviarnos un correo electr\u00f3nico a <a href=\"mailto:MPSII@regenxbio.com\">MPSII@regenxbio.com.<\/a><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-9498aaa callout-column elementor-invisible\" data-id=\"9498aaa\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b2c1b4e card elementor-widget elementor-widget-text-editor\" data-id=\"b2c1b4e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>Preguntas espec\u00edficas del estudio<\/h3>\n<p>Para preguntas espec\u00edficas del estudio, como la elegibilidad, p\u00f3ngase en contacto con un centro del estudio. La informaci\u00f3n de contacto de los centros del estudio puede encontrarse en <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03566043\">ClinicalTrials.gov<\/a> (identificador n.\u00ba NCT03566043). <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dc72258 card elementor-widget elementor-widget-text-editor\" data-id=\"dc72258\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>Profesionales sanitarios<\/h3><p>Si usted es un profesional sanitario y desea obtener m\u00e1s informaci\u00f3n sobre nuestros estudios para pacientes con MPS II, p\u00f3ngase en contacto con nosotros en <a href=\"mailto:medinfo@regenxbio.com\">medinfo@regenxbio.com<\/a>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Un tratamiento en investigaci\u00f3n \u00fanico para la mucopolisacaridosis tipo II (s\u00edndrome de Hunter) REGENXBIO, l\u00edder mundial en terapia g\u00e9nica con VAA, est\u00e1 actualmente inscribiendo participantes en un ensayo cl\u00ednico de RGX-121, una terapia g\u00e9nica \u00fanica en investigaci\u00f3n para el posible tratamiento de la mucopolisacaridosis tipo II, tambi\u00e9n conocida como MPS II o s\u00edndrome de Hunter. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":386,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"class_list":["post-438","page","type-page","status-publish","has-post-thumbnail","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Si parece que su hijo puede calificar, el equipo del estudio puede programar una visita de selecci\u00f3n inicial para comenzar a determinar la elegibilidad y revisar el formulario de consentimiento informado con usted en detalle. El proceso de determinaci\u00f3n de la elegibilidad puede tardar unas semanas.<\/title>\n<meta name=\"description\" content=\"REGENXBIO is enrolling participants in a clinical trial of RGX-121, an investigational, one-time gene therapy for potential treatment of MPS II (Hunter syndrome).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/campsiitestudy.com\/es\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Si parece que su hijo puede calificar, el equipo del estudio puede programar una visita de selecci\u00f3n inicial para comenzar a determinar la elegibilidad y revisar el formulario de consentimiento informado con usted en detalle. El proceso de determinaci\u00f3n de la elegibilidad puede tardar unas semanas.\" \/>\n<meta property=\"og:description\" content=\"REGENXBIO is enrolling participants in a clinical trial of RGX-121, an investigational, one-time gene therapy for potential treatment of MPS II (Hunter syndrome).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/campsiitestudy.com\/es\/\" \/>\n<meta property=\"og:site_name\" content=\"CAMPSIITE Study\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-09T14:00:24+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/01\/campsiite-share-1024x538.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/01\/campsiite-share-1024x538.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"17 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/campsiitestudy.com\\\/es\\\/\",\"url\":\"https:\\\/\\\/campsiitestudy.com\\\/es\\\/\",\"name\":\"Si parece que su hijo puede calificar, el equipo del estudio puede programar una visita de selecci\u00f3n inicial para comenzar a determinar la elegibilidad y revisar el formulario de consentimiento informado con usted en detalle. El proceso de determinaci\u00f3n de la elegibilidad puede tardar unas semanas.\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/campsiitestudy.com\\\/es\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/campsiitestudy.com\\\/es\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/campsiitestudy.com\\\/es\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/campsiitestudy.com\\\/wp-content\\\/uploads\\\/2023\\\/01\\\/campsiite-share.jpg\",\"datePublished\":\"2022-08-10T18:19:11+00:00\",\"dateModified\":\"2023-06-09T14:00:24+00:00\",\"description\":\"REGENXBIO is enrolling participants in a clinical trial of RGX-121, an investigational, one-time gene therapy for potential treatment of MPS II (Hunter syndrome).\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/campsiitestudy.com\\\/es\\\/#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/campsiitestudy.com\\\/es\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\\\/\\\/campsiitestudy.com\\\/es\\\/#primaryimage\",\"url\":\"https:\\\/\\\/campsiitestudy.com\\\/wp-content\\\/uploads\\\/2023\\\/01\\\/campsiite-share.jpg\",\"contentUrl\":\"https:\\\/\\\/campsiitestudy.com\\\/wp-content\\\/uploads\\\/2023\\\/01\\\/campsiite-share.jpg\",\"width\":1200,\"height\":630},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/campsiitestudy.com\\\/es\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/campsiitestudy.com\\\/es\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Home\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/campsiitestudy.com\\\/es\\\/#website\",\"url\":\"https:\\\/\\\/campsiitestudy.com\\\/es\\\/\",\"name\":\"CAMPSIITE Study\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/campsiitestudy.com\\\/es\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/campsiitestudy.com\\\/es\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/campsiitestudy.com\\\/es\\\/#organization\",\"name\":\"CAMPSIITE Study\",\"url\":\"https:\\\/\\\/campsiitestudy.com\\\/es\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\\\/\\\/campsiitestudy.com\\\/es\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/campsiitestudy.com\\\/wp-content\\\/uploads\\\/2022\\\/08\\\/campsiite_logo_tm.svg\",\"contentUrl\":\"https:\\\/\\\/campsiitestudy.com\\\/wp-content\\\/uploads\\\/2022\\\/08\\\/campsiite_logo_tm.svg\",\"width\":343,\"height\":68,\"caption\":\"CAMPSIITE Study\"},\"image\":{\"@id\":\"https:\\\/\\\/campsiitestudy.com\\\/es\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Si parece que su hijo puede calificar, el equipo del estudio puede programar una visita de selecci\u00f3n inicial para comenzar a determinar la elegibilidad y revisar el formulario de consentimiento informado con usted en detalle. El proceso de determinaci\u00f3n de la elegibilidad puede tardar unas semanas.","description":"REGENXBIO is enrolling participants in a clinical trial of RGX-121, an investigational, one-time gene therapy for potential treatment of MPS II (Hunter syndrome).","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/campsiitestudy.com\/es\/","og_locale":"es_ES","og_type":"article","og_title":"Si parece que su hijo puede calificar, el equipo del estudio puede programar una visita de selecci\u00f3n inicial para comenzar a determinar la elegibilidad y revisar el formulario de consentimiento informado con usted en detalle. El proceso de determinaci\u00f3n de la elegibilidad puede tardar unas semanas.","og_description":"REGENXBIO is enrolling participants in a clinical trial of RGX-121, an investigational, one-time gene therapy for potential treatment of MPS II (Hunter syndrome).","og_url":"https:\/\/campsiitestudy.com\/es\/","og_site_name":"CAMPSIITE Study","article_modified_time":"2023-06-09T14:00:24+00:00","og_image":[{"url":"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/01\/campsiite-share-1024x538.jpg","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_image":"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/01\/campsiite-share-1024x538.jpg","twitter_misc":{"Tiempo de lectura":"17 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/campsiitestudy.com\/es\/","url":"https:\/\/campsiitestudy.com\/es\/","name":"Si parece que su hijo puede calificar, el equipo del estudio puede programar una visita de selecci\u00f3n inicial para comenzar a determinar la elegibilidad y revisar el formulario de consentimiento informado con usted en detalle. El proceso de determinaci\u00f3n de la elegibilidad puede tardar unas semanas.","isPartOf":{"@id":"https:\/\/campsiitestudy.com\/es\/#website"},"primaryImageOfPage":{"@id":"https:\/\/campsiitestudy.com\/es\/#primaryimage"},"image":{"@id":"https:\/\/campsiitestudy.com\/es\/#primaryimage"},"thumbnailUrl":"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/01\/campsiite-share.jpg","datePublished":"2022-08-10T18:19:11+00:00","dateModified":"2023-06-09T14:00:24+00:00","description":"REGENXBIO is enrolling participants in a clinical trial of RGX-121, an investigational, one-time gene therapy for potential treatment of MPS II (Hunter syndrome).","breadcrumb":{"@id":"https:\/\/campsiitestudy.com\/es\/#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/campsiitestudy.com\/es\/"]}]},{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/campsiitestudy.com\/es\/#primaryimage","url":"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/01\/campsiite-share.jpg","contentUrl":"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2023\/01\/campsiite-share.jpg","width":1200,"height":630},{"@type":"BreadcrumbList","@id":"https:\/\/campsiitestudy.com\/es\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/campsiitestudy.com\/es\/"},{"@type":"ListItem","position":2,"name":"Home"}]},{"@type":"WebSite","@id":"https:\/\/campsiitestudy.com\/es\/#website","url":"https:\/\/campsiitestudy.com\/es\/","name":"CAMPSIITE Study","description":"","publisher":{"@id":"https:\/\/campsiitestudy.com\/es\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/campsiitestudy.com\/es\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/campsiitestudy.com\/es\/#organization","name":"CAMPSIITE Study","url":"https:\/\/campsiitestudy.com\/es\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/campsiitestudy.com\/es\/#\/schema\/logo\/image\/","url":"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2022\/08\/campsiite_logo_tm.svg","contentUrl":"https:\/\/campsiitestudy.com\/wp-content\/uploads\/2022\/08\/campsiite_logo_tm.svg","width":343,"height":68,"caption":"CAMPSIITE Study"},"image":{"@id":"https:\/\/campsiitestudy.com\/es\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/campsiitestudy.com\/es\/wp-json\/wp\/v2\/pages\/438","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/campsiitestudy.com\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/campsiitestudy.com\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/campsiitestudy.com\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/campsiitestudy.com\/es\/wp-json\/wp\/v2\/comments?post=438"}],"version-history":[{"count":0,"href":"https:\/\/campsiitestudy.com\/es\/wp-json\/wp\/v2\/pages\/438\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/campsiitestudy.com\/es\/wp-json\/wp\/v2\/media\/386"}],"wp:attachment":[{"href":"https:\/\/campsiitestudy.com\/es\/wp-json\/wp\/v2\/media?parent=438"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}